Robbins Chapter 3 Morphology Flashcards
1
Q
Morphology of activated macrophages in granulomas
A
in H & E stain- pink granular cytoplasm with indistinct boundaries
are called epithelioid cells
2
Q
Morphology of giant cells in granulomas
A
multinucleated, large mass of cytoplasm
come from fusion of multiple activated macrophages
3
Q
What causes the central zone of necrosis in granulomas
A
combination of hypoxia and free radical mediated injury
gross appearance of caseous necrosis
4
Q
What granulomas do not have a necrotic center?
A
Crohns, sarcoidosis, and foreign body reactions
called “noncaseating”
5
Q
What is associated with healing of granulomas?
A
fibrosis
