Chapter 6- Amyloidosis

Question 1

What occurs during Amyloidosis?

Answer 1

Extracellular deposits of fibrillar proteins cause tissue damage and functional compromise
Progressive accumulation causes pressure atrophy of adjacent cells

Question 2

How are abnormal fibrils produced in Amyloidosis?

Answer 2

aggregation of misfolded proteins making them insoluble

Question 3

What do fibrillar deposits bind in Amyloidosis?

Answer 3

proteoglycans and glycoaminoglycans

Question 4

How to diagnose Amyloidosis?

Answer 4

tissue biopsy

Question 5

Associated Disease with primary Amyloidosis, precursor protein

Answer 5

multiple myeloma, Ig light chain

Question 6

Associated Disease with secondary Amyloidosis, precursor protein

Answer 6

chronic inflammatory conditions, SAA

Question 7

Associated Diseases with Hemodialysis-associated Amyloidosis, precursor protein

Answer 7

Chronic renal failure, B2 microglobulin

Question 8

Organs involved in Amyloidosis secondary to chronic inflammatory disorders (6)

Answer 8

kidneys!, liver, spleen, LNs, adrenals, thyroid

Question 9

Organs involved in Amyloidosis associated with plasma cell proliferations (6)

Answer 9

heart, GI, respiratory, peripheral nerves, skin, tongue

Question 10

What stain is used for Amyloids

Answer 10

Congo Red

Question 11

Initial Clinical Features of Amyloidosis

Answer 11

weakness, weight loss, light headedness, syncope