Chapter 6- Sjogren Syndrome

Question 1

Characteristics of Sjogren Syndrome

Answer 1

chronic
dry eyes
dry mouth

Question 2

Clinical consequences of Keratoconjunctivitis sicca (4)

Answer 2

dry eyes
blurred vision
burning eyes
itching eyes

Question 3

Clinical consequences of Xerostomia (4)

Answer 3

dry mouth
difficulty swallowing solid foods
decrease in taste
cracks in mouth

Question 4

How does Sjogren Syndrome occur? (3)

Answer 4

Immunologically mediated destruction of lacrimal and salivary glands
Lymphocyte infiltration
Fibrosis

Question 5

Epidemiology of Sjogren Syndrome

Answer 5

women aged 50-60

Question 6

Other clinical features of Sjogren Syndrome (7)

Answer 6

parotid gland enlargement
dryness of nasal mucosa
recurrent bronchitis and pneumonitis
synovitis
diffuse pulmonary fibrosis
peripheral neuropathy
renal involvement

Question 7

Renal involvement in Sjogren syndrome (3)

Answer 7

renal tubular acidosis
uricosuria
phosphaturia

Question 8

Pathology of Sjogren syndrome

Answer 8

biopsy of the lip to examine salivary glands

essential for diagnosis of Sjogren syndrome

Question 9

Early pathology of Sjogren syndrome

Answer 9

mixture of polyclonal T and B cells

Question 10

Later pathology of Sjogren syndrome

Answer 10

dominant B-cell clone causing marginal zone lymphoma