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(1) VMCB > (RNA VIRUSES) Lesson 16: Flaviviridae > Flashcards

(RNA VIRUSES) Lesson 16: Flaviviridae Flashcards

1
Q

General description of Flaviviridae

A
  1. The viruses are spherical, 40–60 nm in diameter with an icosahedral capsid and a tightly adherent envelope containing two or
    three virus-encoded proteins depending on the genus
  2. Positive-sense, single-stranded RNA
  3. Replicate in the cytoplasm
  4. Has Two genera of veterinary importance, Flavivirus and Pestivirus
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2
Q

The name of the family Flaviviridae is derived from the Latin word _______ meaning ________

A

✔ flavus
✔ yellow and referring to the virus of yellow fever

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3
Q

what type of RNA is Flaviviridae

A

single-stranded RNA

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4
Q

type of replication of Flaviviridae

A

Positive-sense

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5
Q

Flaviviridae replicate in the

A

cytoplasm

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6
Q

Flaviviridae two genera of veterinary importance

A

Flavivirus and Pestivirus

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7
Q

Most viruses in this genus are transmitted by arthropods and
cause encephalitis

A

genus Flavivirus

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8
Q

Most viruses in the genus Flavivirus are transmitted by ______ and
cause ________

A

arthropods
encephalitis

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9
Q

which are transmitted directly or indirectly, cause bovine viral diarrhoea, border disease and classical swine fever

A

Pestiviruses

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10
Q

Pestiviruses, which are transmitted directly or indirectly, cause what diseases?

A

✔ bovine viral diarrhoea
✔ border disease
✔ classical swine fever (hog cholera)

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11
Q

Pestiviruses, are transmitted ________, cause bovine viral diarrhoea, border disease and classical swine fever (hog cholera)

A

directly or indirectly

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12
Q

hog cholera also known as

A

classical swine fever (CSF)

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13
Q

Flaviviridae

The different viruses under the genus Pestivirus are antigenically diverse, antigenically cross-reactive and display an overlapping host spectrum.

A
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14
Q

These viruses can cross-infect
other ruminants and swine

A

Bovine viral diarrhoea virus
Border disease virus

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15
Q

Bovine viral diarrhoea virus and border disease virus can cross-infect these animals

A

other ruminants and swine

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16
Q

Viruses in the family Flaviviridae that cause OIE-listed diseases.

A
  1. Japanese encephalitis virus
  2. West Nile virus
  3. Bovine viral diarrhoea virus 1
  4. Bovine viral diarrhoea virus 2
  5. Classical swine fever virus
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17
Q

Zoonotic viruses of Flaviviridae

A

✓ Louping ill virus
✓ Japanese
encephalitis
✓ West Nile virus

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18
Q

Causes inapparent infection, acute disease
(bovine viral diarrhoea) and sporadic fatal
infection (mucosal disease).

A

Bovine viral
diarrhoea virus 1
and 2

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19
Q

Infection of pregnant animals may result in
abortion, congenital defects or persistent
infection (immunotolerance)

A

Bovine viral
diarrhoea virus 1
and 2

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20
Q

Important infection of pregnant ewes and
cause of abortion or congenital abnormalities
(hairy shaker lambs)

A

Border disease virus (sheep)

21
Q

Border disease virus cause an important infection of pregnant ewes and
cause of abortion or congenital abnormalities
like?

A

hairy shaker lambs (sheep)

22
Q

Economically significant disease.

A

Classical swine
fever (hog cholera)
virus

23
Q

Highly contagious, generalized infection that
is frequently fatal.

A

Classical swine
fever (hog cholera)
virus

24
Q

Present in specific regions of Europe.
Transmitted by the tick Ixodes ricinus.
Produces encephalitis in sheep

A

Louping ill virus

25
Q

Louping ill virus is transmitted by the _________

A

tick Ixodes ricinus

26
Q

Louping ill virus is transmitted by the tick Ixodes ricinus.
Produces what disease in sheep?

A

encephalitis

27
Q

Nervous signs, abortion and congenital
tremor are features of the disease

A

Classical swine
fever (hog cholera)
virus

28
Q

FLAVIVIRIDAE

features of the disease
caused by classical swine
fever (hog cholera)
virus

A
  1. nervous signs
  2. abortion
  3. congenital
    tremor
29
Q

Widespread distribution in Asia.
Transmitted
by mosquitoes. Water birds are reservoir
host.

A

Japanese
encephalitis

30
Q

Japanese
encephalitis
is transmitted
by?

A

mosquitoes

31
Q

are reservoir
host of Japanese
encephalitis

A

Water birds

32
Q

West Nile virus
are transmitted by?

A

mosquitoes

33
Q

are the
natural hosts of West Nile virus

A

birds

34
Q

Sporadic cause of serious CNS
disease in humans and horses

A

West Nile virus

35
Q

Occurs in parts of sub-Saharan Africa.
Causes generalized infection, hepatitis and
abortion. Transmitted by mosquitoes

A

Wesselsbron virus

36
Q

Wesselsbron virus causes what conditions

A
  1. generalized infection
  2. hepatitis
  3. abortion
37
Q

Wesselsbron virus is transmitted by?

A

mosquitoes

38
Q

Outbreaks of progressive paresis and
paralysis in turkeys in Israel and South
Africa. Mosquito-borne virus

A

Israel turkey
meningoencephalitis
virus

39
Q

Israel turkey
meningoencephalitis
virus
causes an outbreaks of these conditions in turkeys in Israel and South
Africa.

A

progressive paresis and
paralysis

40
Q

Mosquito-borne virus

A

Israel turkey
meningoencephalitis
virus

41
Q

Infection with this virus is common in cattle
populations worldwide

A

bovine viral diarrhoea virus (BVDV)

42
Q

bovine viral diarrhoea virus (BVDV) geographical distribution

A

Worldwide

43
Q

The virus is responsible for acute disease (bovine viral diarrhoea) and a chronic
syndrome associated with persistent infection (mucosal disease).

A

bovine viral diarrhoea virus (BVDV)

44
Q

chronic
syndrome associated with persistent infection

A

mucosal disease

45
Q

Isolates of BVDV can be segregated into two genotypes now considered
separate species.

ENUMERATE

A

✓ BVDV 1 (classical BVDV isolates)
✓ BVDV 2 (atypical BVDV
isolates)

46
Q

Both BVDV 1 and BVDV 2 can exist as one of two biotypes based on their
activity in cell cultures: what are these activities?

A
  1. cytopathic (due to mutation)
  2. non-cytopathic (common
    in cattle)
47
Q

Cell culture activity oAF BVDV 1&2 due to mutation

A

cytopathic

48
Q

Cell culture activity of BVDV 1&2 common
in cattle

A

non-cytopathic

(1) VMCB (13 decks)

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