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DD/BL unit 3 > rheumatology > Flashcards

rheumatology Flashcards

1
Q

DIP, PIP, 1st CMC, knees, hips, first MTP, cervical/lumbar

A

OA

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2
Q

Cartilage disease

A

OA

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3
Q

OA: DIP/PIP/MCAP/CMC/Wrist?

A

DIP/PIP/CMC

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4
Q

RA: DIP/PIP/MCAP/CMC/Wrist?

A

PIP/MCP/Wrist

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5
Q

OA: Inflam/noninflam

A

non inflammatory

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6
Q

Inflammatory diseases include:

A

RA, cyrstals, spondyloarthropathies, SLE, vasculitis, polymyositis, dermatomyositis

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7
Q

Pseudogout: Synovial fluid is _____?

A

inflammatory with Ca pyophosphate crystals - rhomboid, birefriengent positive

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8
Q

Exercise is good

A

OA

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9
Q

OA: cytokines

A

IL1, NO, PG, TNFa, IL6, IL17, IL18

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10
Q

complement activation, adipokines

A

OA

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11
Q

Symmetric synovitis

A

RA

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12
Q

Shared epitope

A

RA

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13
Q

QKRAA, HLA DR4/1

A

RA

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14
Q

RF IgG immune complex

A

RA

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15
Q

Citrulline - antiCCP ab

A

Ra

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16
Q

Modulation/amplification of local immune response - antigen recognition

A

RA

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17
Q

MSU

A

Gout

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18
Q

Purine

A

gout

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19
Q

Uricase

A

lacks –> gout

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20
Q

Gout cuased by overproductin/underexcretion?

A

underexcretion

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21
Q

Gout Diagnosed

A

arthrocentesis

22
Q

Needle, negative brefirngent

A

Grout

23
Q

PPi metabolism from chondrocutes

A

pseudogout

24
Q

Rhomboid, positive birefringent

A

pseudogout

25
Q

apolipoprotein B coating inhibits phagocytosis

A

pseudogout

26
Q

Sacroilitis

A

spondyloarthropathies

27
Q

Enthesitis

A

spondyloarthropathies

28
Q

spondyloarthropathies synovium

A

TNF alpha

29
Q

spondyloarthropathies HLA?

A

HLA-B27 2%; relative 20%

30
Q

Lower extremity arthritis

A

reactive arthritis

31
Q

dactylitis

A

reactive arthritis

32
Q

misdirected recognition of self as foreign

A

SLE

33
Q

ANtigen driven CD4 T cells

A

SLE

34
Q

B cell autoreactive stimulation - peripheral abnormalities

A

SLE

35
Q

polygenic C4A null allele/HLADR3

A

SLE

36
Q

ANA +

A

SLE (95%)

37
Q

Ab to platelets

A

SLE - clotting

38
Q

IMmune complex = immuno floresencents

A

lumpy bumpy

39
Q

Palpable purpura

A

vascular permeability

40
Q

antigen driven vascular inflammation

A

vasculiity

41
Q

cANCA

A

PR3 - GPA wegners

42
Q

PR3, GPA wegners – _ ANCA

A

c

43
Q

pANCA

A

MPO, microscopic polyangitis MPA

44
Q

MPO, microscopic polyangitis MPA

A

pANCA

45
Q

intersitial lung disease

A

PM/DM

46
Q

ANti-aminoacyl tRNA synthetase

A

cytoplasm

47
Q

Anti-jo-1

A

antihistadyl tRNA synthease

48
Q

CD8 endomysial distribution

A

PM

49
Q

CD4 - perivascular

A

DM

50
Q

Culture of DM/PM

A

no live cultures can be done

DD/BL unit 3 (16 decks)

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