Dermal structures and diseases

Question 1

Dermis ranges in thickness from ___-___mm

Answer 1

1-4

Question 2

Epidermis gets nutritional support from dermis because

Answer 2

no blood vessels

Question 3

Downward projectin of epidermis is known as ________?

Answer 3

epidermal rete

Question 4

Epidermal rete interdigitate with upward projection of the ______

Answer 4

dermal papillae

Question 5

epidermal rete interlock with dermal papillae for ______ and _____

Answer 5

strength of adherence

Increases the surface area = nutritional to epidermis

Question 6

Epidermal ridges = aka ?

Answer 6

fingerprints

Question 7

Dermis is composed predominately of ____, ____, and ____

Answer 7

collagen fibers, elastic fibers, ground substance

Question 8

Most common type of collagen?

Answer 8

type 1

Question 9

Collagen type in fetal dermis

Answer 9

type 3

Question 10

Collagen ___ in basement membrane zone in the ____ junction

Answer 10

4

dermoepidermal

Question 11

Collagen __ attaches epidermis to dermis

Answer 11

7

Question 12

Procollagen synthesized ____ within ___

Answer 12

intracellulary

fibroblasts

Question 13

Procollagen structures

Answer 13

3 separate chain (alpha helical Gly-X-Y proline/hydroxyproline)
Straition 68 intervals

Question 14

Procollagen chain are Gly-X-Y; X/Y typically?

Answer 14

proline

hydroxyproline

Question 15

Collagen fibrils assembled ____

Answer 15

extracellularly

Question 16

Co factors required to synthesize collagen fibrils ___

Answer 16

vitC

Question 17

Deficient vit C is called ___ and symptoms includes:

Answer 17

scurvy

fail to heal, abn hair, fragile BV, teeth fall out

Question 18

Scurvy is a classic example of ____ in ____

Answer 18

acquired abnormality in collagen production

Question 19

Ehlers-Danols syndrome (EDS) is a group of related disorder of _____

Answer 19

collagen synthesis

COngenital abnormality in collagen formation

Question 20

4 major clinical features of ehlers Danlos syndrome

Answer 20

skin hyperextensibility
joint hypermobility
tissue fragility
poor wound healing

Question 21

Collagen fibers provide skin with _____; elastic fibers provide skin with ___

Answer 21

tensile strength; resiliency (ability to return)

Question 22

collagen fibers form large eosinophilic/basophilic bundles?

Answer 22

eosinophilic

Question 23

Elastic fibers are ____philic?

Answer 23

argyrophilic - silver stains

Question 24

Solar elastosis is:

Answer 24

acquired disorder of elastic

Question 25

Accumulation of significant sunlight exposure leads to ______, appear ___ staining material under microscope

Answer 25

degeneration of elastic fibers | basophilic

Question 26

pseudoxanthoma elasticum PXE is a _______ disorder

Answer 26

inherited elastic disorder

Question 27

PXE is caused by a mutation in gene encoding for _____

Answer 27

multidrug resistance complex

Question 28

In PXE, elastic fibers of dermis become ____ and results in a characteristic ____ color

Answer 28

enlarged, tangled, calcified purple blue color (elastic fibers in BV also damaged - hypertension/bleeding disorder in eye)

Question 29

Ground substance is used to describe ____

Answer 29

gelatinous material between collagen bundles, ealstic fibers, appendageal structures of dermis

Question 30

Two glycosaminoglycans:

Answer 30

hyaluronic acids, dermatan sulphate

Question 31

Ground substance produced from ____

Answer 31

fibroblasts

Question 32

Pure hyaluronic acid can be used to ___

Answer 32

costmetic filler | Natural substance that absorbs a lot of water

Question 33

Suprapapillary plate =

Answer 33

capillary structures in skin in uppermost portion of papillary dermis

Question 34

Auspitz sign

Answer 34

remove thickened scales of poriasis = pinpoint bleeding

Question 35

Warts = aka ?

Answer 35

Verruca - benign - virally induced neoplasm = increase dblood supply

Question 36

Leukocytoclastic vasculitis involves ____

Answer 36

post capillary venules because of immune complexes | Strep, allergy/hep C

Question 37

Vasculitis manifest as _____

Answer 37

palpable purpura

Question 38

unmyelinated C fibers with a ________ rate; after entering spinal cord with ___ neurons whos axons cross to opposite site of body

Answer 38

slow conduction | secondary

Question 39

Congenitla insensitivity to pain mutation in _____?

Answer 39

neurotrophic tyrosine receptor kinase 1 - nerve growth factor recetpr

Question 40

Three parts of hair follicles

Answer 40

Infundibulum, isthmus, matrical area

Question 41

hair growth period

Answer 41

anagen

Question 42

hair growth resting phase

Answer 42

telogen

Question 43

hair growth in transition

Answer 43

catagen

Question 44

androgenic alopecia

Answer 44

pattern baldness - minaturized, finer, lie higher in dermis | Treat with finasteride - block testosterone conversion

Question 45

oil secreting glands

Answer 45

sebaceous glands

Question 46

acne caused by 3 things

Answer 46

plugging of ostia by hyperkeratootic debris, accumulation of oil, Propionibacterium acnes

Question 47

Eccrine gland is a ___ secretion - without ___ or ____

Answer 47

merocrine apocrine blebbing holocrine shedding

Question 48

sweating is mediated by ____ of the ANS, triggered via ___

Answer 48

sympathetic | Acetylcholine

Question 49

Apocrine secretion is ___, apical portion of secretory cell cytoplasm pinches off and enter lumen

Answer 49

decapitation | initially odorless - later contact normal bacterial flora

Question 50

Chromohidrosis is ?

Answer 50

colored sweat

Question 51

Apoeccrine glands are ___ sweat glands, found chiefly in the ___

Answer 51

hybrid; axilla | cholinergic stimuli - secrete 10x eccrine