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DD/BL unit 3 > Hemostasis > Flashcards

Hemostasis Flashcards

1
Q

Factor 1 aka ?

A

Fibrinogen

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2
Q

Factor II aka ?

A

prothrombin

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3
Q

Factor III aka ?

A

Tissue Factor

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4
Q

Factor V aka?

A

Proaccelerin, labile factor

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5
Q

Factor VII aka ?

A

Proconvertin

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6
Q

Factor VIII aka ?

A

Anti-hemophilic factor

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7
Q

Factor IX aka ?

A

christmas factor

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8
Q

Factor X aka?

A

Stuart prower factor

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9
Q

Factor XI aka?

A

Plasma thromboplastin antecedent

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10
Q

Factor XII aka?

A

Hageman factor

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11
Q

Factor XIII

A

Fibrin stabilizing factor

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12
Q

Serine proteases (list)

A

factor XII, prekallikrein, factor XI, factor IX, factor X, Factor VII, Factor II
(2, 7, 9, 10, 11, 12, PK)

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13
Q

Vit K dependent proteases

A

Factor II, VII, IX, X, protein C, “Protein S”

2, 7, 9, 10, C, S

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14
Q

Extrinsic tenase made of

A

TF + VIIa

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15
Q

Intrinsic tenase made of

A

IXa + VIIIa

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16
Q

Prothrombinase complex

A

Xa + Va

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17
Q

Contact factors include:

A

HMWK, PK, FXII

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18
Q

Describe intrinsic coagulation pathway up to Xa

A

XII, PK, HWMK –> XIIa –> XIa –> IXa (+VIII) –> Xa

12, 11, 9, 8, 10, 5, 2

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19
Q

Describe the common coagulation pathway

A

Xa (+Va) –> IIa/thrombin –>Fibrin and XIIIa

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20
Q

Describe extrinsic coagulation pathway

A

TF + VIIa –> Xa (+Va) –> THrombin –> Fibrin and XIIIa

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21
Q

Enzyme complex include _____ + ______ + Ca + Phospholipid surface

A

protease, cofactor

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22
Q

Vit K causes a post translational modification to _____?

A

gamma carboxy glutamic acid residue

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23
Q

Warfarin acts by

A

blocking vit K reductase enzyme (depletes vit K)

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24
Q

vWF two main function is:

A
  1. platelet adhesion (vWF to subendothelium)

2. Carrier for factor VIII (t1/2 2-12 hr)

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25
5 main coagulation roles of thrombin
1. activate platelets 2. Cleaves fibrinogen 3. Activates V and VIII (amplification) 4. XIIIa - stablize fibrin 5. XIa (intrinsic pathway amp)
26
Thrombin roles for fibrinolysis
1. Activates protein C | 2. Activates TAFI
27
Antithrombin III can inhibit _____ and ______
Xa and Thrombin
28
Unfractionated heparin (cofactor for ________) increase efficiency binding to ___________ and _________
Antithrombin | Xa and Thrombin
29
LMWH (co factor for ______) increase efficiency binding to _______?
only Xa
30
Fondaparinux is =?
a pentasaccharide (for heparin) - only helps bind with Xa
31
C1 (esterase) inhibitor regulates ______ and ______
1. Classic complement pathway (immunology) | 2. (Vascular) Contact factor (XIa, XIIa, Kallikrein)
32
Protein C effect is to _______; protein C is classified as _____
Decrease (Va and VIIIa) thrombin - anticoagulant
33
Protein C zymogen is activated by _____
thrombin
34
Protein C binds to ________ (cofactor)
Thrombomodulin
35
______ inhibits protein C binding to thrombomodulin
proinflammatory agents
36
Factor V leiden definition?
Glu--> Arg mutation - resistant to protein C "APC Resistant"
37
Factor V leiden effect?
Venous thromboembolism
38
Warfarin can initially cause _______________? Why?
Transient Hypercoagulable state Protein C is vit K dependent/short half life Protein C deficient = cannot lower thrombin --> more clot
39
Protein C Deficiency would lead to?
thrombosis
40
TFPI = aka?
Tissue Factor Pathway Inhibitor (TFPI)
41
TFPI mechanism:
inhibits extrinisic coagulation pathway | Binds Xa --> binds TF-VIIa => Quad complex (TF/TFPI/Xa/VIIa)
42
TFPI function/results:
prevents atherosclerosis
43
Plasminogen --> _______
plasmin
44
Plasmin is a ________ ___________, that breaks down _____, ______, _____
serine protease Fibrin Fibrinogen ECM proteins
45
tPA = aka?
tissue plasminogen activator
46
tPA can activate _____ in the prescence of ______
plasminogen, fibrin
47
tPA is cleaved by ____
Plasmin
48
uPA = aka?
urokinase plasminogen activator
49
uPA is synthesized by ?
kidney + endothelial cells (and tumor cells)
50
uPA was released as:
prourokinase/scu-PA
51
uPA works by binding to ____, cleaved by ____ which then can cleave ____
fibrin clot, plasmin, plasmin
52
Deficiency in uPA or tPA
Thrombosis
53
TAFI activated by?
THrombin-thrombomodulin complex --> exopeptidase
54
TAFI = Aka?
thrombin activatable fibrinolysis inhibitor
55
TAFI acts on?
C terminal of proteins (Fibrin) = less plasminogen binding site on fibrin
56
TAFI regualtes ?
down regulate: PLasmin and clot lysis
57
PAI-1 = aka?
plasminogen activator inhibitor 1
58
PAI-1 is stored mostly in
alpha granules in platelets
59
PAI-1 inhibits ____ and ____
tPA and uPA
60
PAI1: Deficiency or excess effect
``` Excessive bleeding Thrombotic events (excess) ```
61
a2 - antiplasmin
Binds plasmin 1:1 and inactivates | F13 - links a2-antiplasmin to fibrin
62
a2-antiplasmin deficiency
bleeding disorder
63
Endothelial cells express what anticoagulant?
1. heparan sulfate & Dermatan sulfate 2. Thrombomodulin 3. TFPI
64
Endothelial cells express what fibrinolytic factors
tPA | uPA
65
Endothelial cells express what anti-plt factors
1. PGI2 & NO | 2. AMP/Adenosin (from ADP) enzymes
66
Primary hemostasis concerns with
platelet activation, aggregation, adhesion
67
Secondary hemostasis concerns with
fibrin clot
68
protein S is _____ dependent
vit K
69
Protein S distribution
60% boudn to C4bBP (regulate complement - inactive), 40% free
70
Protein S is a cofactor to _____?
Protein C/APC

DD/BL unit 3 (16 decks)

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