Immunomodulators Flashcards
Immunomodulator are = (define)
drugs/combination that change function of immune system
Broad examples of immunomodulator
NSAID Disease modifying antirheumatic drug Glucocorticoids Biological response modifiers mAb (tumors)
Murine = ?
mAb of mice “omab”
Chimeric = ?
mAb (human C domains, mouse V domains)
“-ximab”
Humanized = ?
CDR mouse, all else human
“-zumab”
Fully humanized =
all human “umab”
mAb for inflammation
target TNF alpha
infliximab, adalimumab, certolizumab
BiTE = ?
bispecific T cell engager = coupled antibody B to T cell (CD19 - CD3)
used for ALL
biological response modifiers target ____ or ____
cytokines or receptors; or cellular communication/signaling molecules
Natural killer cells are ______ _____ ______
large granular lymphocytes (LGL)
ADCC = ?
antibody dependent cell mediated cytotoxicity
NK cells are part of the ____ immune system
innate
NK has 2 receptors and who they target
NK receptor - for stressed cells
FcyR = targets antibody on cells
NK cells are ___ independent
MHC - good for tumor treatment (T cell from a tumor)
Passive antibody therapy in cancer uses:
antibody to tumor associated antigens -> ADCC
Immunotoxin (tag antibody with toxin)
CAR = chimeric antigen receptor used for?
T cell from cancer pt - transformed via lentivirus vector - transformed CTL bind to tumor with high affinity (no MHC restriction)
Immuno suppression in organ transplant has 3 main adverse effects:
- inherently toxic
- Increase risk of cancer
- Increase opportunisitic infections
Azathioprine/6-mecaptopurine - does what
decrease DNA synthesis; mRNA transcription
Mycophenolate mofetil function:
less toxic, decrease DNA/mRNA syn
Glucocoticoids function:
anti-inflam; used during rejection episodes
Cyclosporine - A function:
decrease IL2 production, down reg mac’s APC - lessen stim of T cells
Tacrolimus function:
synergize with cyclosporine A - decrease syn/response to IL2
Sirolimus/Rampamycin function:
binds FKBP-12 - no effect on calcineurin. Inhibits mTOR (T cell activation)
anti-thymocyte globulin (ATGAM) function:
made in animals - immunized with human thymocytes - prepare recipients for bone marrow transplant/acute organ rejection
mAbs function:
bind to CD3, IL2 receptor (too much mAb to CD3 = cytokine storm)
