Immunomodulators

Question 1

Immunomodulator are = (define)

Answer 1

drugs/combination that change function of immune system

Question 2

Broad examples of immunomodulator

Answer 2

NSAID
Disease modifying antirheumatic drug
Glucocorticoids
Biological response modifiers
mAb (tumors)

Question 3

Murine = ?

Answer 3

mAb of mice “omab”

Question 4

Chimeric = ?

Answer 4

mAb (human C domains, mouse V domains)

“-ximab”

Question 5

Humanized = ?

Answer 5

CDR mouse, all else human

“-zumab”

Question 6

Fully humanized =

Answer 6

all human “umab”

Question 7

mAb for inflammation

Answer 7

target TNF alpha

infliximab, adalimumab, certolizumab

Question 8

BiTE = ?

Answer 8

bispecific T cell engager = coupled antibody B to T cell (CD19 - CD3)
used for ALL

Question 9

biological response modifiers target ____ or ____

Answer 9

cytokines or receptors; or cellular communication/signaling molecules

Question 10

Natural killer cells are ______ _____ ______

Answer 10

large granular lymphocytes (LGL)

Question 11

ADCC = ?

Answer 11

antibody dependent cell mediated cytotoxicity

Question 12

NK cells are part of the ____ immune system

Answer 12

innate

Question 13

NK has 2 receptors and who they target

Answer 13

NK receptor - for stressed cells

FcyR = targets antibody on cells

Question 14

NK cells are ___ independent

Answer 14

MHC - good for tumor treatment (T cell from a tumor)

Question 15

Passive antibody therapy in cancer uses:

Answer 15

antibody to tumor associated antigens -> ADCC

Immunotoxin (tag antibody with toxin)

Question 16

CAR = chimeric antigen receptor used for?

Answer 16

T cell from cancer pt - transformed via lentivirus vector - transformed CTL bind to tumor with high affinity (no MHC restriction)

Question 17

Immuno suppression in organ transplant has 3 main adverse effects:

Answer 17

1. inherently toxic
2. Increase risk of cancer
3. Increase opportunisitic infections

Question 18

Azathioprine/6-mecaptopurine - does what

Answer 18

decrease DNA synthesis; mRNA transcription

Question 19

Mycophenolate mofetil function:

Answer 19

less toxic, decrease DNA/mRNA syn

Question 20

Glucocoticoids function:

Answer 20

anti-inflam; used during rejection episodes

Question 21

Cyclosporine - A function:

Answer 21

decrease IL2 production, down reg mac’s APC - lessen stim of T cells

Question 22

Tacrolimus function:

Answer 22

synergize with cyclosporine A - decrease syn/response to IL2

Question 23

Sirolimus/Rampamycin function:

Answer 23

binds FKBP-12 - no effect on calcineurin. Inhibits mTOR (T cell activation)

Question 24

anti-thymocyte globulin (ATGAM) function:

Answer 24

made in animals - immunized with human thymocytes - prepare recipients for bone marrow transplant/acute organ rejection

Question 25

mAbs function:

Answer 25

bind to CD3, IL2 receptor (too much mAb to CD3 = cytokine storm)