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4th Year SB > Rheum > Flashcards

Rheum Flashcards

1
Q

Saddle nose

A

GPA

[can also be sarcoidosis]

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2
Q

Azathioprine plus allopurinol = ?

A

pancytopenia

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3
Q

Which drug causes reactivation of latent TB

A

TNF alpha inhibitor (etanercept, infliximab)

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4
Q

What DMARD causes interstitial pneumonitis

A

methotrexate

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5
Q

What DMARD causes black tarry stools

A

NSAIDs

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6
Q

what DMARD is nephrotoxic

A

Gold, penicillamine

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7
Q

what are the traid of Sx of Behcet’s Syndrome

A

Visual loss, mouth ulcers and genital ulcers

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8
Q

trimethoprim + methotrexate = ?

A

fatal

acute megaloblastic pancytopenia

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9
Q

boy with back pain and a sore eye

A

AS

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10
Q

what is PMR linked with

A

temporal arteritis

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11
Q

antibodies seen in SLE

A

anti-Sm
Anti-DNA binding
ANA
Anti Ro + La

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12
Q

antibodies seen in RA

A

Anti-CCP

RF

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13
Q

antibodies seen in Sjogrens Syndrome

A

Anti Ro and La

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14
Q

antibodies seen in Limited Systemic Sclerosis

A

Anti-centromere

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15
Q

antibodies seen in Diffuse Systemic Sclerosis

A

Anti-Scl-70

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16
Q

antibodies seen in mixed CTD

A

Anti-RNP

17
Q

antibodies seen in polymyositis

A

Anti-Jo-1

18
Q

antibodies seen in anti-phospholipid syndrome

A

Anti-Cardiolipin

Lupus anti-coagulant

19
Q

side effects of methrotrexate

A

liver cirrhosis
myelosuppression
pneumonitis

20
Q

side effects of sulfasalazine

A

rashes

oligospermia

21
Q

side effects of hydroxychloroquine

A

retinopathy

corneal deposits

22
Q

side effects of prednislone

A 
cushings 
osteoporosis 
impaired glucose tolerance 
hypertension 
cataracts
23
Q

side effects of gold

A

proteinuria

24
Q

side affects of penicillamine [can be used in Wilson’s disease also]

A

proteinuria [membranous glomerulonephritis]

exacerbation of myathenia gravis

25
Q

side effects of infliximab

A

reactivation of TB

26
Q

allergy to what drug may be a contraindication to starting sulfasalazine

A

aspirin

27
Q

what antibiotics are risk factor for tendon rupture

A

quinones i.e. ciprofloxacin

28
Q

what heart problem is Ehler-Danlos associated with

A

aortic regurgitation

29
Q

what is ANA linked with

A

SLE, scleroderma, Sjögren’s syndrome, polymyositis/dermatomyositis, mixed connective tissue disease, drug-induced lupus, and autoimmune hepatitis

30
Q

what type of hypersensitivity reaction is SLE

A

Type 3 = immune complexes

31
Q

what is Felty Syndrome

A

splenomegaly and neutropenia in a patient with rheumatoid arthritis

32
Q

what are drugs that can cause drug-induced lupus

A

isoniazid, phenytoin, hydralazine

33
Q

antibodies seen in drug-induced lupus

A

ANA positive

Anti-histone antibodies

34
Q

If a FRAX score > 10% = ?

A

get a DEXA scan

35
Q

first line treatment for Raynouds

A

Calcium Channel Blocker

36
Q

Periarticular erosions on x-ray = ?

A

RA

4th Year SB (22 decks)

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