Renal Flashcards
Pre-renal causes of acute kidney injury
dehydration haemorrhage sepsis cardio-renal hepato-renal
Renal cause of AKI
glomerulonephtis
interstitial nephritis
acute tubular necrosis
vascular - renal vein thrombosis
post-renal cause of AKI
renal stones
prostate hypertrophy
bladder/cervical/prostate cancer
what is interstitial nephritis typically related too
new medications
e.g. antibiotics, NSAIDs, diruetics
what is a buzzword for interstitial nephritis
urine eosinophilia
what is typical history of acute tubular necrosis
Hx of hypotension, fluid depletion, nephrotoxics
what is common results of acute tubular necrosis
low urine osmolality [due to impairment in concentrating urine]
increased urinary sodium
how does renal vein thrombosis present
flank pain + haematuria
often mistaken for renal calculi
think if patient is at risk i.e. SLE
Mx of AKI
catheterise + accurate fluid balance
causes of chronic kidney disease [6 causes]
hypertension renovascular diabetes reflux glomerulonephritis PCKD
how is secondary hyperparathyroidism Tx
due to Vit D deficiency
i.e. replace Vit D
how is tertiary hyperparathyroidism Tx
phosphate binders
parathyroidectomy
how does hypertensive disease affecting the kidneys present
proteinuria [NOT haematuria]
both kidneys will be similar in size
Mx = control BP
how does renovascular kidney disease present
older patients, M > F
abdominal bruit
majority present with chronic renal failure
what might precipitate someone with renovascular kidney disease presenting with AKI
starting nephrotoxic drug ie. ACEi
Ix for renovascular kidney disease and results
1st line = renal ultrasound (see different size kidneys)
Gold standard = MR Renal Angiography
Mx for renovascular kidney disease
Conservative e.g. statin, manage BP
how does diabetic kidney disease present
microalbuminaemia [NO haematuria]
IX and Mx for diabetic kidney
Ix = Urine albumin to creatinine ratio
Mx = glycaemic control, anti-hypertensives (ACEi)
what is inheritance pattern for PCKD
autosomal dominant
Sx of PCKD
Abdo pain, Haematuria, Hypertension, Abdominal Mass
Typically have a FMHx of sudden death in exam questions
Ix for PCKD
1st line = renal USS
Mx for PCKD
control BP
analgesia - avoid NSAIDs
what is the 2 typical presenting symptoms of nephritic syndrome
haematuria
hypertension
what is the 2 typical presenting symptoms of nephrotic syndrome
proteinuria
oedema
common nephritic syndromes
Rapidly progressive GN
IgA nephropathy
Alport syndrome
common nephrotic syndromes
Minimal change disease
Membranous GN
Focal Segmental Glomerulosclerosis
Amyloidosis
Diabetic Nephropathy
What causes a mixed nephritic and nephrotic picture
Diffuse proliferative GN
Membranoproliferative GN
Post-Strep GN
Presentation, causes, and treatment of Rapidly progressive GN
Presentation = rapid onset, AKI
Causes
- Goodpastures
- ANCA positive vasculitis
Tx
- high dose steroids
- cyclophosphamide
what antibody is associated with Goodpastures
Anti-GBM antibodies
what are the 2 ANCA positive vasculitis that cause Rapidly progressive GN
Granulomatosis with polyangiitis (formerly called Wegener’s)
Eosinophilic granulomatosis with polyangiitis (EGPA) (formerly called Churg Struss)
- associated with pANCA
how does IgA nephropathy present and how is it treated
presentation = young adult, haematuria following URTI
Tx = supportive
how does diffuse proliferative GM present
Post-streptococcal
common in SLE or patients on drugs post-kidney-transplant
hows does membranoproliferative present
following renal transplant
steroids may be effective
who gets minimal change nephrotic syndrome and what is Tx
children
have normal biopsy result
Tx = steroid
what is the commonest cause of nephrotic syndrome in the UK
membranous GN
what are causes of membranous GN
infections
rheumatoid drugs (gold/pencillamine)
malignancy
1/3 resolve
1/3 proteinuric
1/3 CKD
what is the Tx of membranous GN
Mx = steroids + immunosuppressants