Ortho Flashcards
Tx cascade for OA
1st line = topical analgesia i.e. topical NSAID (diclofenac)
2nd line = paracetamol + local analgesia
3rd line = NSAID + paracetamol + local analgesia (+PPI)
4th line = Opioid (e.g. oxycodone) + paracetamol + NSAID + local analgesia
Adjunct = IA Corticosteroid injection
Surgical options = arthrodesis, THR/TKR
what is mnemonic for OA on x-ray
L – loss of joint space
O – osteophytes
S – sclerosis
S - subchondral cysts
what are the Ix results for RA (antibodies)
Auto-Ab – Rheumatoid factor, Anti-CCP
Bloods – CRP raised
how does RA present
swelling, morning stiffness, pain, deformity, loss of function, nodules
affects small joints and c-spine
what might be seen in hands in RA
Boutonniere deformity
Ulnar deviation
Swan-Neck deformity
Mx of RA
DMARD monotherapy +/-bridging prednisolone
= Methotrexate
TNF inhibitors
- infliximab
side effects of methotrexate
myelosuppression – monitor FBC + LFTs
pneumonitis
what are the seronegative/HLA B27 arthritis
AS
Psoriatic arthritis
Reactive arthritis
Inflammatory Bowel Disease arthritis
how does AS present
Chronic inflammation – spine and sacroiliac joints fusion of joints
Young males
Symptoms – pain, stiffness, hip/knee arthritis
Ix of AS
X-Ray
Key Buzzwords = ‘sacroiliitis’ ‘bamboo spine’, ’squaring of lumbar vertebrae’
Mx of AS
- important
1st line = NSAIDs, physio, EXERCISE [gets much better w/ exercise]
2nd line = Anti-TNF therapy = etanercept/adalumumab
DMARDS only useful if peripheral joint disease
Adjunct = IA corticosteroids
how does psoriatic arthritis present
30% skin psoriasis
Asymmetrical, oligoarthritis, sacroiliitis, spondylitis, dactylitis and enthesitis
nail changes: pitting, onycholysis, arthritis DIP joints
Ix of psoriatic arthritis
x-ray
- pencil-in-cup appearance
what are common causative organisms for reactive arthritis
GI - campylobacter, shigella, salmonella, yersinia
GU - chlamydia, gonorrhoea
Sx of reactive arthritis
urethritis, uveitis, arthritis
“can’t see, can’t pee, can’t climb a tree”
Mx of reactive arthritis
Rx underlying infection, symptomatic relief, +/- DMARDS
what is gout and what causes it
Urate crystals in joints – hyperuricaemia
Renal underexcretion or excessive intake of alcohol, red meat, seafood
how does gout present
Classic site – 1st MTP joint, ‘podagra’
CF – intensely painful, hot, swollen joint, tophi
Ix for gout
1st line = joint aspiration
- Synovial fluid with needle shaped, negative birefringence
Mx of gout
Acute = NSAIDS, colchicine, intra-articular corticosteroid
Long term = allopurinol
what can allopurinol interact with and what can it cause
Azathioprine
- can cause pancytopenia
what is pseudogout
1 - Calcium pyrophosphate crystals – causing acute arthritis
2 - Chondrocalcinosis - deposits in cartilage/soft tissue, but no inflammation
Ix of pseudogout
joint aspirate
= Synovial fluid w/ positively birefringent crystals
Mx of pseudogout
NSAIDS, corticosteroids, +/- colchicine
hydroxychloroquinine
causes of septic arthritis by age = adults/ivdu, children, young adult
Staphylococcus aureus – adults/IVDU
Haemophilus influenza – children
Neisseria gonorrhea – young adults
Mx of septic arthritis
Ix – urgent joint aspirate BEFORE giving Abx
Tx – Abx, surgical washout
SLE antibodies
anti-dsDNA.
Remember C3/C4 low in active disease
sjogrens antibodies
anti RO/anti LA
systemic sclerosis antibodies
limited = anti-centromere
diffuse = anti-scl-70
polymyositis antibodies
anti-Jo-1
mixed connective antibodies
anti-RNP
Sx of Anti-Phospholipid Syndrome
CLOT
Coagulation defect Levido reticularis Obstetric problems (miscarriages) Thrombocytopenia
what is surgery reserved for in back pain
nerve root compression
single level disc degeneration/prolapse
?Sudden shooting pain while performing heavy lifting
prolapsed disc
?Lowgrade fever, local tenderness at L3
discitis
?Lorry driver, stiff, tender
mechanical back pain
?Person with sciatica and back pain and wants something to be done . They are also obese
weight loss programme + physiotherapy 1st line
what causes radiculopathy and how does it present
Gelatinous nucleus pulposis can ‘herniate’ or ‘prolapse’ = impinge on nerve
Neuralgic burn, severe tingling
what does an L3/4 prolapse cause and what are the Sx
L4 root entrapment
- pain to medial ankle, loss of quad power, reduced knee jerk
what does an L4/5 prolapse cause and what are the Sx
L5 root entrapment
- pain to dorsum of foot, reduced power on dorsiflexion