Rhabdovirus and Paramixoviruses

Question 1

what is the type of virus that rabies is

Answer 1

-ssrna like VSV
-non segmented
-cytoplasmic replication

Question 2

what type of virus are paramyxoviruses

Answer 2

-ssrna like mumps and measles
-non segmented
-cytoplasmic replication

Question 3

rhabdovirus glycoproteins name

Answer 3

G

Question 4

true ro false: rabies looks like a bullet

Answer 4

true

Question 5

true or false: measles has a thicccc membrane

Answer 5

false it is floppy

Question 6

structural proteins of measles

Answer 6

HN and fusion protein

Question 7

true or false: rabies a an old disease

Answer 7

true
First described in Mesopotamia in 2300 BC,
rabies has been recognized in humans and
animals for many centuries.

Question 8

true or false: rabies is always pretty mucvh fatal

Answer 8

true

Question 9

rabies: disease usually occures with the onset of…

Answer 9

Disease usually occurs with the onset of an acute
encephalomyelitis, often preceded by periods of
excitement or agitation, and quickly followed by
coma and death.

Question 10

Hypersalivation and hydrophobia are prominent features oF

Answer 10

rabies

Question 11

how do you get rabies:

Answer 11

you get bitten by an animal that has rabies, virus then moves up the PNS into the CNS into the brain

Question 12

how did Pasteur make his rabies vaccine

Answer 12

-In 1881, he began studies of rabies in animals.
-He developed methods of producing attenuated virus preparations
-Progressively drying rabbit spinal cords after experimental infection
-These preparations, when inoculated into animals would protect from challenge with virulent virus without leading to the disease itself
-This was the first artificially produced virus vaccine.
-in 1885 a kiddo was treated with his vaccine and did not get rabies after getting bit by a rabid dog

Question 13

Where are rabies still prevalent

Answer 13

in asia and in africa but in Canada there is pretty much none
-last guy in can dies in 2007

Question 14

Most common reservoir of rabies

Answer 14

silver haired bat

Question 15

Pathogenic paramyxoviruses

Answer 15

-Mumps virus – salivary gland and testicular infection
-Measles virus ‐ which caused around 733,000 deaths worldwide in 2000
-Respiratory syncytial virus (RSV), the major cause of bronchiolitis and pneumonia in
infants and children.
-Human parainfluenza viruses (HPIV) are the second most common causes of respiratory
tract disease in infants and children.

Question 16

what are Henipaviruses

Answer 16

Henipaviruses are zoonotic pathogens, occurring naturally in animal hosts, but also able
to infect humans.

Question 17

where do you get mumps

Answer 17

-PAROTID GLAND
-SUBMANDIPULAR GLAND
-subblingual gland
-salivary gland
-balls

Question 18

what is the special quick to measle

Answer 18

RNA POL BINDS TO A CISTRON ONE AT A TIME

Question 19

order of the measles proteins made

Answer 19

N, P, M, F, G, L

Question 20

Measles:Pausing

Answer 20

Pausing
‐ polyadenylation at poly(U) tract
by repetitive retranscription
Attenuation
‐ polymerase falling off template
during “stuttering” process

Question 21

true or false: rna pol makes subgenomic rna for rabies

Answer 21

true

Question 22

Features that make VSV an excellent candidate as a vaccine vector

Answer 22

-It is a weak human pathogen does not undergo genetic recombination or genomic
reassortment and has no known transforming properties.
-VSV does not integrate any of its genomic material into host cell.
-As a vaccine strategy, VSV is known to elicit strong humoral and cellular immune
responses in vivo and naturally infects at mucosal surfaces.
-This offers an alternative less invasive intranasal route of immunization that has been
shown to induce both mucosal and systemic.
-Recombinant VSVs can be generated to accommodate large foreign gene inserts or
multiple genes into their genomes.
-VSV grows to high titers in vitro, thus facilitating rapid purification of large amounts of
virus and viral proteins.