Herpes virus Flashcards
When was herpes research more popular?
the 70s
Structure of herpes viruses
-ds-DNA genome 125,000-229,000 bp
-Icosahedral symmetry of virus capsid
-162 capsomeres
-Surrounding tegument
-Envelope membrane derived from nuclear membrane by budding
How many ORFs in HSV
there are 70
multiple orfs are overlapping tho
True or false: all human herpesviruses have identical EM morpohology
true
True or false: all herpesviruses are ubiquitous infecting a majority of all hhumans
true
True or false: you can get rid of herpes viruses
false: the infection remain latent lifelong and may reactivate
How many herpes viruses exist:
-Herpes simplex virus type I (HSV1 or HHV1)
-Herpes simplex virus type II (HSV2 or HHV2)
-Varicella-zoster virus (VZV or HHV3)
-Epstein-Barr virus (EBV or HHV4)
-Cytomegalovirus (CMV or HHV5)
-Human herpesvirus 6 (HHV6)
-Human herpesvirus 7 (HHV7)
-Kaposi sarcoma-associated (KSHV or HHV8)
virus
Primary target cell, pathophysiology, site of latency and means of spread of HSV1
-Primary Target: Mucoepithelial
-Cell Pathophysiology: oral and/or genital herpes (predominatly orofacial)
-Site of latency: neuron
-Means of Spread: close contact (oral or STI)
Primary target cell, pathophysiology, site of latency and means of spread of HSV2
-Primary Target: Mucoepithelial
-Cell Pathophysiology: oral and/or genital herpes (predominatly orofacial)
-Site of latency: neuron
-Means of Spread: close contact (oral or STI)
Primary target cell, pathophysiology, site of latency and means of spread of VZV
-Primary Target: Mucoepithelial
-Cell Pathophysiology: chickenpox and shingles
-Site of latency: neuron
-Means of Spread: close contact or respiratrory
Primary target cell, pathophysiology, site of latency and means of spread of EBV
-Primary Target: B cells/epithelial cells
-Cell Pathophysiology:
infectious Mononucleosis
EBV‐associated lymphoproliferative diseases:
Burkitt’s lymphoma
EBV‐positive
Hodgkin lymphoma
Post‐transplant
lymphoproliferative
syndrome (PTLD
-Site of latency: B cells
-Means of Spread: Close contact,
transfusions, tissue transplant, and congenital transmission
Primary target cell, pathophysiology, site of latency and means of spread of CMV
-Primary Target: Monocytes and epithelial cells
-Cell Pathophysiology: infectious monocleosis like syndrome aka retinitis
-Site of latency: monocyte
-Means of Spread: saliva, urine, blood. breast milk
Primary target cell, pathophysiology, site of latency and means of spread of Roseolovirus
-Primary Target: t cells
-Cell Pathophysiology: sixth disease or roseaola infantum or exanthem subitum
-Site of latency: t cells
-Means of Spread: respiratory and close contact
Primary target cell, pathophysiology, site of latency and means of spread of KSHV
-Primary Target: lymphocytes
-Cell Pathophysiology: Kaposi’s sarcoma
Primary cavity lymphoma
-Site of latency: b cells
-Means of Spread: Close contact (sexual),
saliva?
True or false: HSV1 and HSV2 have serologically distinct membrane glycoproteins
true
True or false hsv 1 and 2 have similar m, manifestations when infecting similar sites
true
What makes hsv 1 and 2 different?
different but converging epidemiological patterns
True or false: primates can’t get infected by herpes
false they can
True or false: HSV Urogenital infection HSV1 10‐30% HSV2 70‐90%
true
True or false: Neonatal infection HSV 1 75‐85% HSV 2 15‐25%
HSV 2 75‐85% HSV1 15‐25%
MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis): percentages of people
‐ 30‐100% of population infected by age 5
‐ 30‐50% of middle class children
‐ 80‐100% of poorer populations
MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis):
Primary infection
‐ primary infection often asymptomatic
but may present as severe gingivostomatitis
‐ paradoxically:
‐ primary infection is most often asymptomatic
‐ but, when symptomatic, it is usually severe
MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis): incubation
2-12 days
WHERE CAN HSV INFECT PEOPLE
eye, hand, or other skin sites may be infected
de novo or by autoinnoculation
