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MIMM 324 > Herpes virus > Flashcards

Herpes virus Flashcards

1
Q

When was herpes research more popular?

A

the 70s

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2
Q

Structure of herpes viruses

A

-ds-DNA genome 125,000-229,000 bp
-Icosahedral symmetry of virus capsid
-162 capsomeres
-Surrounding tegument
-Envelope membrane derived from nuclear membrane by budding

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3
Q

How many ORFs in HSV

A

there are 70
multiple orfs are overlapping tho

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4
Q

True or false: all human herpesviruses have identical EM morpohology

A

true

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5
Q

True or false: all herpesviruses are ubiquitous infecting a majority of all hhumans

A

true

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6
Q

True or false: you can get rid of herpes viruses

A

false: the infection remain latent lifelong and may reactivate

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7
Q

How many herpes viruses exist:

A

-Herpes simplex virus type I (HSV1 or HHV1)
-Herpes simplex virus type II (HSV2 or HHV2)
-Varicella-zoster virus (VZV or HHV3)
-Epstein-Barr virus (EBV or HHV4)
-Cytomegalovirus (CMV or HHV5)
-Human herpesvirus 6 (HHV6)
-Human herpesvirus 7 (HHV7)
-Kaposi sarcoma-associated (KSHV or HHV8)
virus

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8
Q

Primary target cell, pathophysiology, site of latency and means of spread of HSV1

A

-Primary Target: Mucoepithelial
-Cell Pathophysiology: oral and/or genital herpes (predominatly orofacial)
-Site of latency: neuron
-Means of Spread: close contact (oral or STI)

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9
Q

Primary target cell, pathophysiology, site of latency and means of spread of HSV2

A

-Primary Target: Mucoepithelial
-Cell Pathophysiology: oral and/or genital herpes (predominatly orofacial)
-Site of latency: neuron
-Means of Spread: close contact (oral or STI)

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10
Q

Primary target cell, pathophysiology, site of latency and means of spread of VZV

A

-Primary Target: Mucoepithelial
-Cell Pathophysiology: chickenpox and shingles
-Site of latency: neuron
-Means of Spread: close contact or respiratrory

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11
Q

Primary target cell, pathophysiology, site of latency and means of spread of EBV

A

-Primary Target: B cells/epithelial cells
-Cell Pathophysiology:
infectious Mononucleosis
EBV‐associated lymphoproliferative diseases:
Burkitt’s lymphoma
EBV‐positive
Hodgkin lymphoma
Post‐transplant
lymphoproliferative
syndrome (PTLD
-Site of latency: B cells
-Means of Spread: Close contact,
transfusions, tissue transplant, and congenital transmission

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12
Q

Primary target cell, pathophysiology, site of latency and means of spread of CMV

A

-Primary Target: Monocytes and epithelial cells
-Cell Pathophysiology: infectious monocleosis like syndrome aka retinitis
-Site of latency: monocyte
-Means of Spread: saliva, urine, blood. breast milk

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13
Q

Primary target cell, pathophysiology, site of latency and means of spread of Roseolovirus

A

-Primary Target: t cells
-Cell Pathophysiology: sixth disease or roseaola infantum or exanthem subitum
-Site of latency: t cells
-Means of Spread: respiratory and close contact

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14
Q

Primary target cell, pathophysiology, site of latency and means of spread of KSHV

A

-Primary Target: lymphocytes
-Cell Pathophysiology: Kaposi’s sarcoma
Primary cavity lymphoma
-Site of latency: b cells
-Means of Spread: Close contact (sexual),
saliva?

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15
Q

True or false: HSV1 and HSV2 have serologically distinct membrane glycoproteins

A

true

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16
Q

True or false hsv 1 and 2 have similar m, manifestations when infecting similar sites

A

true

17
Q

What makes hsv 1 and 2 different?

A

different but converging epidemiological patterns

18
Q

True or false: primates can’t get infected by herpes

A

false they can

19
Q

True or false: HSV Urogenital infection HSV1 10‐30% HSV2 70‐90%

A

true

20
Q

True or false: Neonatal infection HSV 1 75‐85% HSV 2 15‐25%

A

HSV 2 75‐85% HSV1 15‐25%

21
Q

MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis): percentages of people

A

‐ 30‐100% of population infected by age 5
‐ 30‐50% of middle class children
‐ 80‐100% of poorer populations

22
Q

MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis):
Primary infection

A

‐ primary infection often asymptomatic
but may present as severe gingivostomatitis
‐ paradoxically:
‐ primary infection is most often asymptomatic
‐ but, when symptomatic, it is usually severe

23
Q

MANIFESTATIONS OF HSV INFECTION
(i.e. Herpes labialis and Herpes genitalis): incubation

A

2-12 days

24
Q

WHERE CAN HSV INFECT PEOPLE

A

eye, hand, or other skin sites may be infected
de novo or by autoinnoculation

25
Q

What happens to people without immune compromise that get HSV

A

‐ usually no serious sequelae
‐ treatment is optional

26
Q

where does the recurrent infection of HSV appear

A

same site as primary infection

27
Q

where does the latency of hsv appear

A

in sensory ganglia

28
Q

REactivations of hsv are often attributed to:

A

‐ concurrent infection, fever
‐ stress, menses, exposure to UV light, etc

29
Q

True or false: small quantities of virus may periodically be shed asymptomatically

A

true

30
Q

steps of hsv appearance

A

-clear fluid blisters
-whiteish blisters due to white blood cells
-then blisters break open

31
Q

VZV: what is the difference between varicella (chickenpox) and zoster(shingles)

A

-Varicella
a primary infection
always disseminated
-Shingles:
a local recurrence of latent infection

32
Q

true or false: when you have VZV after that you can’t get reinfected and if so why

A

true
all subsequent manifestations in such individuals represent reactivation of latent virus from sensory ganglia

MIMM 324 (26 decks)

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