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MY Virology FINAL > Rhabdoviridae > Flashcards

Rhabdoviridae Flashcards

1
Q

Rhabdoviridae is ___ shaped

A

bullet

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2
Q

What are the two important viruses of Rhabdoviridae?

A

Rabies virus

Vesicular stomatis virus

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3
Q

Rabies virus is very ____in the environment

A

Fragile

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4
Q

Rabies is non _____, meaning that the rabies virus does not destroy ____

A

non cytopathic

Rabies does not destroy neurons

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5
Q

What are the inclusion bodies associated with Rabies?

A

Negri bodies

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6
Q

What rhabdoviridae virus is cytopathic, has no inclusion bodies and is stable in the environment?

A

Vesicular stomatitis virus

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7
Q

What Rhabdoviridae virus is non cytopathic, has inclusion bodies, and is fragile in the environment?

A

Rabies virus

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8
Q

Envelope of Rhabdoviridae contains the ___ protein

A

G

(glycoprotein)

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9
Q

Spike in the envelope induces the ____ antibodies

A

neutralizing

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10
Q

Rhabdovirus produces ____ particles during replication at a high percentage

A

defective interfering particles (DI)

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11
Q

Rhabdoviruses are ____, and inactivated by UV light

A

thermoliable

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12
Q

What is the etiological agent for Rabies virus?

A

genotype 1 Lyssavirus

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13
Q

There is only one serotype of rabies so the _____ will protect against all rabies strains

A

vaccine

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14
Q

____ are very susceptible to rabies

A

rodents

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15
Q

____ are highly susceptible to Rabies and are very epidemiologially important because they carry a very high titer of virus in their saliva and the virus is longer lived in these species

A

Skunks

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16
Q

Dogs and humans are ____ susceptible to rabies

A

moderatly

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17
Q

What strains are there for Genotype 1 rabies virus?

A

Skunk strains- 2

Arctic and red fox strain

Gray fox strain

Dog and coyote strain

Raccoon strain

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18
Q

Rabies is extremely liable when exposed to _____

A

UV light

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19
Q

Most common mode of transmission in rabies virus?

A

bites

scratches

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20
Q

Rabies can also be transmitted via _____ but is not common due to the fragility of the virus

A

aerosol inhalation

*very common in bat cats!

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21
Q

In north america, what kinds of bats are important for the transmission of rabies?

A

fruit

insectoviorous

22
Q

What animal accounts for most cases of cattle infection with rabies?

A

skunks

23
Q

____ are reservoirs of rabies viruses

A

bats

24
Q

____ is very important in maintaining the virulence of the rabies virus

A

moisture

*dry saliva cannot transmit virus

25
Q

True/False: Rabies develops rapidly in hosts

A

False

*it is slow developing

26
Q

Rabies virus first multiplies in _____ cells

A

muscle

27
Q

True/Fale: there is no viremia in rabies virus

A

True

28
Q

In the brain, rabies first multiplies in the ____ system

A

limbic

*why you see behavioral changes in animal- “furious” form with biting ect.

29
Q

What is the cause of death in Rabies virus?

A

respiratory paralysis

30
Q

The most important organ epidemiologically in Rabies is the _____

A

salivary glands

*only time the animal can trasmit rabies

31
Q

True/False: In rabies the animals develop hydrophobia because they are afraid of water

A

False

They are not able to swallow

32
Q

What is a characteristic sign of rabies in cattle?

A

Bellowing

salivation

33
Q

Where is the virus multiplying during the paralytic form of Rabies?

A

neocortex

*no longer showing aggression

34
Q

What is the best way to prevent rabies virus?

A

vaccination

35
Q

Not all Rabies virus positive brains show ____

A

negri bodies

36
Q

neutralizing antibodies are directed against ___ protiens

A

G

37
Q

What is the etiological agent of Vesicular stomatis?

A

Vesiculovirus

38
Q

What pathological finding is associated withe vesicular stomatitis?

A

ulcers

39
Q

What hosts will you find vesicular stomatitis in?

A

cattle, horses and swine

40
Q

True/False: Vesicular Stomatitis is a worldwide disease

A

False

*not a world wide disease

41
Q

What serotype is most important in Vesiular Stomatitis?

A

New Jersey serotype

*most virulent and widely distributed

42
Q

Is there cross protection between the New Jersey and indiana serotypes of Vesicular Stomatitis?

A

No

43
Q

How is vesicular stomatitis transmitted?

A

direct contact

arthropods

44
Q

Vesicular Stomatitis causes loss of ____ and horses and there is a very short ___

A

condition

short immunity

45
Q

Do we vaccinate in Vesicular Stomatitis?

A

No

*Quarantine for 30 days

46
Q

Bovine ephemeral fever is cause by what etiological agent?

A

Bovine ephemerovirus

47
Q

Bovein Ephemeral fever is ____ to north america

A

exotic

48
Q

What drops dramatically with Bovine ephemeral fever?

A

milk production

49
Q

Bovine Ephemeral fever has 100% ____ transmission

A

arthropod

*mosquito transmission- Aedes

50
Q

What Disease is has Neutrophilia with a left shift?

A

Bovine Ephemeral fever

MY Virology FINAL (12 decks)

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