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MY Virology FINAL > Adenoviridae > Flashcards

Adenoviridae Flashcards

1
Q

Adenoviridae are (enveloped/nonenveloped) consisting of (double stranded/single stranded) DNA

A

non enveloped

double stranded DNA

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2
Q

Release of progeny occurs via ____

A

cell lysis

*kills the cells they multiply in

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3
Q

What kind of inclusion bodies does Adenoviridae make?

A

Basophilic intranuclear inclusion bodies

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4
Q

Adenoviridae ____ red blood cells

A

hemagglutinates

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5
Q

Adenoviridae virions are ____ in the environment

A

stable

*decontamination is a must

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6
Q

Adenoviridae capsomeres are surrounded by ___ capsomeres

A

5

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7
Q

True/False: There is a carrier state with Adenoviridae

A

True

*carrier for several months after infection has cleared

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8
Q

The penton fibers of Adenoviridae contain the ____

A

VAPS

*viral attachment proteins

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9
Q

The penton fibers of the capside are ___ to host cells

A

toxic

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10
Q

Adenoviruses can cause ____ of immune and inflammatory responses of animals

A

immunosuppression

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11
Q

What ways can Adenovirus cause immunosuppression in a host?

A
  1. down regulate MHC 1
  2. block apopotic pathway
  3. blocks interferons from producing anti-viral proteins
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12
Q

All adenovirus infections are associated with long periods of ____

A

latency

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13
Q

Adenovirus can be ____ in immunosuppressed patients

A

reactivated

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14
Q

Adenovirus is pathogenic in ____ foals with _____

A

Arabian foals

SCID (immunodeficiency)

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15
Q

____immunity is critical in Adenovirus

A

humoral

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16
Q

Infectious Canine Hepatitis is also known as ____

A

Rubarths disease

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17
Q

What animal is used to distinguish infectious canine hepatitis from distemper?

A

ferrets

*resistant to ICH but not distemper

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18
Q

Who are the hosts for Infectious Canine Hepatitis?

A

dogs and bears

19
Q

What is the etiological agent of Infectious canine hepatitis?

A

Canine Adenovirus 1

20
Q

In dogs, Infectious canine hepatitis can be spread in the ___ for more than 6 months

A

urine

21
Q

How is infectious canine hepatitis spread?

A

ingestion or inhalation of secretions, urine, saliva ect.

22
Q

What clinical signs do animals with Infectious canine hepatitis show?

A

Respiratory

Ailmentary

CNS

23
Q

Where does Infectious canine hepatitis replicate?

A

macrophages

24
Q

What sensitivity is an important feature in Infectious canine hepatitis?

A

Type III hypersensativity

25
Q

True/False: Infectious canine hepatitis replicates in neurons

A

False

*does not replicate in neurons

26
Q

What pathogenesis can Infectious canine hepatitis cause?

A

chronic hepatitis

Organ failure

DIC

possible death

27
Q

If antibody titer is low in ICH, the virus with shred ____

A

hepatocytes

*virus can devistate the liver

28
Q

What cells does infectious canine hepatitis infect?

What organs are affected?

A

infects macrophages and endothelial cells

Causes hemorrhage and necrosis in:

liver, kidney, spleen and lungs

29
Q

In order for the animals to fight off infectious canine hepatitis,

what must the antibody titer be?

A

at least [1:500]

30
Q

What does ICH cause in the eyes if the virus enters the aqueous humor?

A

corneal edema (blue eyes)

*normally gone within 21 days

31
Q

What does ICH cause in the kidney?

A

glomerulonephritis

32
Q

What can occur in ICH, due to endothelial cell damage and infarcts in multiple organs?

A

disseminated intravascular coagulation (DIC)

*multi organ failure results

33
Q

ICH is most frequently seen in dogs less than ___ year of age

A

one

34
Q

Mose ICH infections are ___

A

asymptomatic

35
Q

What is the CNS form of infectious canine hepatitis?

A

encephalitis (fox)

*petechial hemorrhage in brain

36
Q

Recovered animals have ___ immunity with ICH

A

solid

37
Q

If puppies have enough ___ then they will not get ICH

A

maternal antibodies

38
Q

What is the key for treatment in ICH?

A

Vaccination

*less than 1% of puppies will get cornea edema that are vaccinated

39
Q

What is another name for Canine infectious tracheobronchitis?

A

Kennel cough

40
Q

Canine infectious tracheobronchitis causes what kind of disease in dogs?

A

upper respiratory tract disease

41
Q

What is the etiological agents for Canine infectious tracheobronchitis?

A

canine adenovirus 2

(also influenza and bordetella bronchiseptica)

42
Q

Kennel cough is highly contagious and transferred mainly via _____

A

aerosolized droplets

43
Q

Is there a vaccine for kennel cough?

A

Yes!- works well

44
Q

Equine adenovirus happens in horses with ____ that lack T and B lymphocytes and is a big killer of these foals

A

SCID

MY Virology FINAL (12 decks)

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