Adenoviridae Flashcards
Adenoviridae are (enveloped/nonenveloped) consisting of (double stranded/single stranded) DNA
non enveloped
double stranded DNA
Release of progeny occurs via ____
cell lysis
*kills the cells they multiply in
What kind of inclusion bodies does Adenoviridae make?
Basophilic intranuclear inclusion bodies
Adenoviridae ____ red blood cells
hemagglutinates
Adenoviridae virions are ____ in the environment
stable
*decontamination is a must
Adenoviridae capsomeres are surrounded by ___ capsomeres
5
True/False: There is a carrier state with Adenoviridae
True
*carrier for several months after infection has cleared
The penton fibers of Adenoviridae contain the ____
VAPS
*viral attachment proteins
The penton fibers of the capside are ___ to host cells
toxic
Adenoviruses can cause ____ of immune and inflammatory responses of animals
immunosuppression
What ways can Adenovirus cause immunosuppression in a host?
- down regulate MHC 1
- block apopotic pathway
- blocks interferons from producing anti-viral proteins
All adenovirus infections are associated with long periods of ____
latency
Adenovirus can be ____ in immunosuppressed patients
reactivated
Adenovirus is pathogenic in ____ foals with _____
Arabian foals
SCID (immunodeficiency)
____immunity is critical in Adenovirus
humoral
Infectious Canine Hepatitis is also known as ____
Rubarths disease
What animal is used to distinguish infectious canine hepatitis from distemper?
ferrets
*resistant to ICH but not distemper
Who are the hosts for Infectious Canine Hepatitis?
dogs and bears
What is the etiological agent of Infectious canine hepatitis?
Canine Adenovirus 1
In dogs, Infectious canine hepatitis can be spread in the ___ for more than 6 months
urine
How is infectious canine hepatitis spread?
ingestion or inhalation of secretions, urine, saliva ect.
What clinical signs do animals with Infectious canine hepatitis show?
Respiratory
Ailmentary
CNS
Where does Infectious canine hepatitis replicate?
macrophages
What sensitivity is an important feature in Infectious canine hepatitis?
Type III hypersensativity