Adenoviridae Flashcards

1
Q

Adenoviridae are (enveloped/nonenveloped) consisting of (double stranded/single stranded) DNA

A

non enveloped

double stranded DNA

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2
Q

Release of progeny occurs via ____

A

cell lysis

*kills the cells they multiply in

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3
Q

What kind of inclusion bodies does Adenoviridae make?

A

Basophilic intranuclear inclusion bodies

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4
Q

Adenoviridae ____ red blood cells

A

hemagglutinates

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5
Q

Adenoviridae virions are ____ in the environment

A

stable

*decontamination is a must

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6
Q

Adenoviridae capsomeres are surrounded by ___ capsomeres

A

5

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7
Q

True/False: There is a carrier state with Adenoviridae

A

True

*carrier for several months after infection has cleared

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8
Q

The penton fibers of Adenoviridae contain the ____

A

VAPS

*viral attachment proteins

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9
Q

The penton fibers of the capside are ___ to host cells

A

toxic

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10
Q

Adenoviruses can cause ____ of immune and inflammatory responses of animals

A

immunosuppression

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11
Q

What ways can Adenovirus cause immunosuppression in a host?

A
  1. down regulate MHC 1
  2. block apopotic pathway
  3. blocks interferons from producing anti-viral proteins
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12
Q

All adenovirus infections are associated with long periods of ____

A

latency

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13
Q

Adenovirus can be ____ in immunosuppressed patients

A

reactivated

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14
Q

Adenovirus is pathogenic in ____ foals with _____

A

Arabian foals

SCID (immunodeficiency)

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15
Q

____immunity is critical in Adenovirus

A

humoral

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16
Q

Infectious Canine Hepatitis is also known as ____

A

Rubarths disease

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17
Q

What animal is used to distinguish infectious canine hepatitis from distemper?

A

ferrets

*resistant to ICH but not distemper

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18
Q

Who are the hosts for Infectious Canine Hepatitis?

A

dogs and bears

19
Q

What is the etiological agent of Infectious canine hepatitis?

A

Canine Adenovirus 1

20
Q

In dogs, Infectious canine hepatitis can be spread in the ___ for more than 6 months

21
Q

How is infectious canine hepatitis spread?

A

ingestion or inhalation of secretions, urine, saliva ect.

22
Q

What clinical signs do animals with Infectious canine hepatitis show?

A

Respiratory

Ailmentary

CNS

23
Q

Where does Infectious canine hepatitis replicate?

A

macrophages

24
Q

What sensitivity is an important feature in Infectious canine hepatitis?

A

Type III hypersensativity

25
True/False: Infectious canine hepatitis replicates in neurons
False \*does not replicate in neurons
26
What pathogenesis can Infectious canine hepatitis cause?
chronic hepatitis Organ failure DIC possible death
27
If antibody titer is low in ICH, the virus with shred \_\_\_\_
hepatocytes \*virus can devistate the liver
28
What cells does infectious canine hepatitis infect? What organs are affected?
infects macrophages and endothelial cells Causes hemorrhage and necrosis in: liver, kidney, spleen and lungs
29
In order for the animals to fight off infectious canine hepatitis, what must the antibody titer be?
at least [1:500]
30
What does ICH cause in the eyes if the virus enters the aqueous humor?
corneal edema (blue eyes) \*normally gone within 21 days
31
What does ICH cause in the kidney?
glomerulonephritis
32
What can occur in ICH, due to endothelial cell damage and infarcts in multiple organs?
disseminated intravascular coagulation (DIC) \*multi organ failure results
33
ICH is most frequently seen in dogs less than ___ year of age
one
34
Mose ICH infections are \_\_\_
asymptomatic
35
What is the CNS form of infectious canine hepatitis?
encephalitis (fox) \*petechial hemorrhage in brain
36
Recovered animals have ___ immunity with ICH
solid
37
If puppies have enough ___ then they will not get ICH
maternal antibodies
38
What is the key for treatment in ICH?
Vaccination \*less than 1% of puppies will get cornea edema that are vaccinated
39
What is another name for Canine infectious tracheobronchitis?
Kennel cough
40
Canine infectious tracheobronchitis causes what kind of disease in dogs?
upper respiratory tract disease
41
What is the etiological agents for Canine infectious tracheobronchitis?
canine adenovirus 2 (also influenza and bordetella bronchiseptica)
42
Kennel cough is highly contagious and transferred mainly via \_\_\_\_\_
aerosolized droplets
43
Is there a vaccine for kennel cough?
Yes!- works well
44
Equine adenovirus happens in horses with ____ that lack T and B lymphocytes and is a big killer of these foals
SCID