Orthomyxoviridae Flashcards
Is influenze a reportable disease?
Yes
Orthomyxovirus has a ____ genome
segmented
All Influenza viruses originally came from _____
aquatic birds
*water fowl
True/False: Orthomyxovirus is fragile in environment
True
Does Orthomyxovirus produce inclusion bodies?
no
True/False: Every influenza virus hemagglutinates
True
Antibodies to ____ proteins neutralize infectivity of the virions
Hemmaglutanin
____ enhances the release of virions by cleaving sialic acid and lowers the viscosity of mucus membranes
Neurominidase
True/False: Neurominidase neutralizes free virions
False
*only reduces the number of progeny virions released but does not neutralize virions
There are ____ possible hemagglutinins and ____ possible neurominidases
16 hemaglutinins (H)
9 neurominidases (N)
What are the different types of Influenzavirus and which one is the most important?
A- most important
B
C
Influenza cells are ____ and kill the cells that they multiply in
cytolytic
Major change involving hemagglutinin genes that results in genetic reassortment of two Influenza viruses that have infected the same cell
antigenic shift
Minor change due to point mutations that alter the binding sites of protective antibodies of the hemagglutinin
antigenic drift
What are the etiological agents of equine influenza?
Equine influenza A/H7N7
Equine Influenza A/H3N8- most important
What does influenza cause in mammals?
Respiratory tract infections
What does Influenza cause in Avian species?
Viremia- systemic infection
respiratory tract, GI tract, CNS
What species is influenza deadly in?
Birds
What type of infection does Equine influenza cause in horses?
Respiratory disease
*pneumonia
Is equine influenza reportable?
yes
True/False: mortality is rare in influenza, excepti in avian species
True
How is equine influenza controlled?
Quarantine for 30 days
Is there a vaccination for Equine influenza?
Yes
What is the etiological agent in canine influenza?
Canine Influenze virus A [H3N8]
Do we vaccinate for canine influenza?
Yes
What kind of disease does canine influenza cause in dogs?
highly contagious respiratory disease
With swine influenza there is a short term ___ stage
carrier
What is the etiological agent of swine influenza?
Influenza A virus subtype H1N1
The severity of Influenza in swine is determined by which nematode?
Ascaris suum
Is there a vaccine for swine influenza?
yes
What are the other names for Avian influeza virus A
bird flu
fowl plague
What is the highly pathogenic etiological agent in avian influenza virus A
Avian influenza A virus [HPAI]
*Kills majority of birds that it infects
What are the reservoir hosts for avian influenza virus A?
water fowl
How are all influenza viruses transmitted?
aerosolization
What is the control for Avian influenza type A?
quarantine and depopulation
What is the important difference between Newcastle disease and Bird flu?
Newcastle- we vaccinate
Bird flu- no vaccination
