Birnaviridae Flashcards
What genus of Birnaviridae leads to infectious bursal disease virus?
avibirnavirus
Birnaviridae is a non enveloped virus with what kind of symmetry?
Icosahedral
Birnaviridae consist of two segments of ____ stranded RNA
double stranded
Where does Birnaviridae replicate in the cell?
cytoplasm
What disease is a highly contagious viral infection of young chickens that has a predilection for the bursa of Fabricius
Infectious Bursal disease
There are two serotypes of Infectious Bursal Disease. What serotype is pathogenic to chickens and causes severe disease?
Serotype 1
What are the three subgroups of Serotype 1 of Infectious Bursal disease?
variant viruses- no mortality
standard virus- some mortality
very virulent virus- high mortality
How is infectious bursal disease transmitted?
fecal oral
direct contact
True/False: Infectious bursal disease is very stable and can survive disinfection
True
What is the target organ of infectious Bursal disease?
Bursa of Fabricius
During infectious bursal disease, replication of the virus in the bursa results in depletion of ____, leading to immunosuppresion
B lymphocytes
Even if a bird recovers from infectious bursal disease, it is susceptible to other infections due to ______.
immunosuppression
Infectious bursal disease triggers both direct and indirect pathways to induce a _____, leading to mortality of the chicken
cytokine storm
What are the clinical signs of an chicken with infectious bursal disease?
ruffled feathers diarrhea dehydration atrophy of the bursa hemorrhage of bursa
How is infectious bursal disease diagnosed?
necropsy- look for swollen or atrophied bursa AGID test (agar gel immunodiffusion)
