Rh Blood Group

Question 1

R1

Answer 1

D, C, e
42% white
17% white

Question 2

R2

Answer 2

D, c, E
14% white
11% black

Question 3

R0

Answer 3

D, c, e
4% white
44% black

Question 4

Rz

Answer 4

D, C, E

Rare white and black

Question 5

r

Answer 5

c, e

37% white, 26% black

Question 6

r’

Answer 6

C, e

2% white and black

Question 7

r”

Answer 7

c, E
1% white
Rare black

Question 8

ry

Answer 8

C, E

Rare black and white

Question 9

Rh1

Answer 9

D
85% white
92% black

Question 10

Rh2

Answer 10

C
68% white
27% black

Question 11

Rh3

Answer 11

E
29% white
22% black

Question 12

Rh4

Answer 12

c
80% white
96% black

Question 13

Rh5

Answer 13

e

98% both

Question 14

Weak D

Answer 14

Genetic: RHD gene codes for weakened expression of D antigen, reduced number of D antigen sites on the RBC membrane, can safely transfuse D+ blood
Due to C: position effect, RHCe allele inherited trans to RHD allele, can safely transfuse D+ blood
Partial D: red blood cells missing one or more portion of the D antigen, cannot transfuse D+ blood

Question 15

Partial D Weak D

Answer 15

RBC missing one or more portions of the D antigen
Due to hybrid gene in which portions of RHD are replaced by corresponding portions of RHCE
Person types D positive
Can form alloanti-D that reacts with all D positive RBC except their own

Question 16

Require Weak D Typing

Answer 16

Donor blood

Baby of Rh negative mother

Question 17

Rh Antibodies

Answer 17

RBC immune
Do not bind complement, but can cause extravascular hemolysis 
Clinically significant 
Can cross placenta 
Enhanced by enzymes

Question 18

Rh Null

Answer 18

Person lack ALL Rh antigens
Can make antibodies to any and all Rh antigens
Demonstrate mild hemolytic anemia
Can only transfuse Rh null blood

Question 19

Cw Antigen

Answer 19

Found in combination with C or c antigen
2% white, rare in black
Anti-Cw seen in both RBC immune and non-immune

Question 20

rhi (Ce) Antigen

Answer 20

Compound antigen
C and e in the cis position
R1R2 is positive for rhi antigen (DCe, DcE)
R0Rz in negative for rhi antigen (Dce/DCE)

Question 21

f (ce) Antigen

Answer 21

c and e in cis position
Compound antigen, but f is a single antigen
anti-f implicated in HDN and HTR

Question 22

G Antigen

Answer 22

Found on red cells with D or C antigen

Question 23

Deletion Phenotype

Answer 23

D-- or -D-
C, c, E, e antigens are absent from the RBC membrane
Very strong D antigen expression 
Can make antibodies to missing antigen 
anti-Rh17 (Hro antibody)