Kidd, Kell, Duffy

Question 1

Kidd Blood Group

Answer 1

Jka, Jkb, Jk3, Jk null

Question 2

Jk3 Antigen

Answer 2

Present with Jka/Jkb antigen

Common antigen

Question 3

Jk Null

Answer 3

Dominant inhibitor gene: ln(Jk), weak expression of Kidd antigens, does not make anti-Jk3
Inheritance of homozygous Jk/Jk genotype: make anti-Jk3

Question 4

Anti-Jk3 Antibody

Answer 4

Most of the antibody reactivity is directed against Jk3

Question 5

Kidd Antibodies

Answer 5

Good complement binding IgG antibody
Detect with polyspecific AHG
Implicated in delayed HTR

Question 6

Kell Blood Group

Answer 6

Phenotype usually includes all of the high frequency antigens plus one low
High frequency: k, jsb, Kpb
Low frequency: K, Jsa, Kpa
Treatment of RBCs with sulfhydral reagents results in Kell null cells

Question 7

Kell Antibodies

Answer 7

anti-K is most common antibody encountered

IgG anti-K and IgM anti-K

Question 8

McLeod Phenotype (Kell)

Answer 8

Lack Kx and Km antigens from RBC membrane
Weakened expression of Kell system antigens
Associated with CGD
Hemolytic picture compensated hemolytic anemia with acanthocytes, reticulocytes

Question 9

Duffy Blood Group

Answer 9

Fya, Fyb, Fyx, Fy3, Fy4, Fy5, Fy (silent)
Codominant alleles, syntenic with Rh gene
No not store well, antigens can elute off the RBC during storage
Fya, Fyb, Fy6 destroyed by enzymes
Fy3 and Fy5 not destroyed

Question 10

Duffy and Malaria

Answer 10

Black people with duffy phenotype Fy(a-b-) have resistance to Plasmodium vivax (causes malaria)
Some areas of West Africa are 100%