P, MNS, Others

Question 1

P Blood Group

Answer 1

Genes code for enzymes that sequentially add sugars to precursor substances
P1, P, Pk, and p (silent)

Question 2

Anti-P

Answer 2

Naturally occuring in Pk phenotype

Question 3

Auto Anti-P

Answer 3

IgG found in PCH
Called the Donath Landsteiner antibody
Binds the RBCs at cold temps and activates C’ at warm
Found in children following a viral infection and people with tertiary syphilis

Question 4

Anti-PP1Pk (Tja)

Answer 4

Clinically significant IgM with a IgG component
Only found in amorph little p phenotype
Seperable anti-P, anti-P1, anti-Pk

Question 5

MNS Blood Group

Answer 5

M, N, S, s, and U

Question 6

Anti-M Antibodies

Answer 6

Some have IgG component in addition to IgM
Reactivity enhanced with increased serum:cell ratio
Some are pH-dependent react best on pH 6.5
Rule out with homozygous cells

Question 7

Anti-S and Anti-s

Answer 7

IgG reactive at 37C and AHG phase

Anti-s is less easily destroyed by enzymes

Question 8

U Antigen and Antibody

Answer 8

Found on glycophorin B at the base next to the RBC membrane

High frequency antigen, resistant to enzymes

Question 9

Diego and Wright

Answer 9

Wra antibodies: can be non-RBC immune IgM or RBC immune IgG

Question 10

Chido/Rogers

Answer 10

High titer, low avidity

RBC immune, IgG, non complement binding

Question 11

Vel

Answer 11

IgM with some IgG present

RBC immune

Question 12

Sda

Answer 12

RBC immune, IgM with few IgG

Shiny refractile agglutination