AIHA Flashcards
1
Q
Tests
A
DAT, antibody ID
Test to search for additional clinically significant, unexpected antibodies
2
Q
Cold Hemagglutinin Disease
A
Pathological cold auto antibodies Tend to have a high titer Broad thermal range of reactivity Anti-I, enhanced with enzyme treated cells Compliment activator IgM
3
Q
Warm AIHA
A
Most common AIHA Moderate to severe hemolytic anemia Frequent hemolysis has an acute onset May ativate complement Do not ID
4
Q
Transfusion for WAIHA
A
Not recommended
Must use least incompatible blood
Transfused with small volumes
Phenotypically similar
5
Q
Drug Dependent Antibodies with Drug Coated Red Cells
A
Drug adsorption method High dose IV Penicillin, Cephalosporins IgG, may have C' DAT is strong positive Reactive with drug coated cells only Gradual hemolysis, extravascular
6
Q
Other Drug depended Antibodies
A
Immune complex Quinidine and Phenacetin IgG or IgM C' may be only globulin Non-reactive eluate, positive with drug coated cells Acute intravascular hemolysis
7
Q
Drug Independent Antibodies
A
Autoantibody production a-methyldopa, L-dopa, aldomet IgG DAT IgG strongly positive Eluate positive with all cells tested Acute onset, severe
8
Q
Nonimmunologic Protein Adsorption
A
Membrane modification Cephalosporins, Cephalothin (Keflin) Many plasma proteins DAT positive due to variety of serum proteins Reacts with everything at AHG phase No hemolysis, positive DAT and IAT
