Retroviruses Flashcards
What two subfamilies make up retroviridae?
Orthoretroviridae and Spumaviridae
What type of genome do retroviruses have?
(+)ssRNA, Diploid, Identiacal copies
What type of virion do retroviruses have?
Enveloped
What unique protein do retroviruses have?
Reverse transcriptase
What proteins do simple retroviruses encode?
GAG, PRO, POL, ENV
What is unique about retrovirus replication?
Reverse transcription (ssRNA to dsDNA) followed by integration into host DNA.
Once retrovirus dsDNA is integrated into host DNA, what happens?
It is endogenous into the host germ line and may disrupt host genes causing disease such as cancer.
Which Human T-Cell Leukemia Virus is most associated with humans?
HLTV-1
How is HTLV-1 transferred?
Person to person (mother-child breastfeeding, needles, blood transfusion, STD), Within host (cell-to-cell)
What disease results from Human T-Cell Leukemia Virus infection?
HTLV-1 Associated Myelopathy / Tropical Spastic Paraparesis (HAM/TSP)
What are the symptoms of HTLV-1 (HAM/TSP)
Bladder control issues progressing to lower back pain and leg weakness or stiffness in hips or knees.
What family of virus does Human Immunodeficiency Virus belong?
Lentivirus
What cells does HIV virus target?
Memory T-cells (CD4+)
What type of genome does HIV have?
(+)ssRNA genome (diploid)
What type of virion does HIV have?
Enveloped
