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Micro Final > Hepatitis Viruses > Flashcards

Hepatitis Viruses Flashcards

1
Q

What are Hepatitis Viruses?

A

Viruses that specifically target the liver

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2
Q

Which Hepatitis Viruses are fecal-orally transmitted?

A

HAV, HEV

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3
Q

Which Hepatitis Viruses are primarilly sexually transmitted?

A

HBV, HCV, HDV

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4
Q

Which Hepatitis Viruses are common in the US?

A

Hepatitis A, B, and C

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5
Q

What virus is Hepatitis A similar to?

A

Poliovirus (Picornovirus)

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6
Q

What family does Hepatitis B virus belong to?

A

Hepadnaviridae

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7
Q

What type of genome does Hepatitis B have?

A

dsDNA

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8
Q

What type of virion does Hepatitis B have?

A

Enveloped

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9
Q

What virus has the smalled genome of the human viruses?

A

Hepatitis B

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10
Q

What is odd about the replication of Hepatitis B Virus?

A

Genome has an RNA intermediate after entering the nucleus.

It also produces many empty particles that do not contain genome.

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11
Q

What are the symptoms of Hepatitis B?

A

Genereal malaise, anorexia, comiting, fatigue, cough, serum-like sickness. Eventually Jaundice

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12
Q

Chronic Hepatitis B disease can lead to?

A

Cirrhosis of the liver which increases the risk of hepatocellular carcinoma

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13
Q

How is Hepatitis B prevented?

A

Recombinant vaccination is available (requires multiple innoculations - injection of synthesized viral particles)

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14
Q

How is chronic Hepatitis B treated?

A

Interferon-alpha therapy.

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15
Q

What is Hepatitis D Virus?

A

Subviral agent.

Requires active HBV infection

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16
Q

What family does Hepatitis C Virus belong to?

A

Flaviviridae

17
Q

What type of genome does Hepatitis C have?

A

(+)ssRNA

18
Q

What type of virion does Hepatitis C have?

A

Enveloped

19
Q

How does translation occur in Hepatitis C virus?

A

Ribosomes recognise Internal Ribosome Entry Site (IRES)

20
Q

How does Hepatitis C Virus differ from Hepatitis B Virus?

A

It is typically milder than HBV but chronic infections occur in approximately 80% of infections

21
Q

How is Hepatitis A contracted?

A

Fecally contaminated food or water - absorbed through intestine and moves to liver via portal system

22
Q

What are the symptoms of Hepatitis A virus?

A

Maliase, anorexia, vomiting, and jaundice

23
Q

What other Hepatitis strain is Hepatitis E virus similar to? How do these two differ?

A

Hepatitis A - but it is life threatening to pregnant women.

24
Q

What is the incubation time for HAV?

A

15-40 days

25
Q

What is the incubation time for HBV?

A

60-180 days

26
Q

What is the incubation time for HCV?

A

60-120 days

27
Q

What is the incubation time for HDV?

A

60-180 days

28
Q

What is the incubation time for HEV?

A

21-42 days

29
Q

Which Hepatitis strains are capable of chronic infections?

A

HBV (5%) HCV (80%) and HDV

30
Q

Which Hepatitis strains are enveloped? Non enveloped?

A

Enveloped - B/C/D

Non-Enveloped - A/E

31
Q

What are the genomes of the different hepatitis strains?

A 
A - (+)ssRNA
B - Circular dsDNA
C - (+)ssRNA
D - (-)ssRNA
E - (+)ssRNA

Micro Final (13 decks)

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