Respiratory Viruses Flashcards
What type of genome does Influenze virus have?
SEgmented (-) ssRNA
What type of virion does Influenza virus have?
Enveloped
What type of genome does Adenovirus have?
dsDNA
What type of virion does Adenovirus have?
Non-enveloped
What type of genome does Rhinovirus have?
(+)ssRNA
What type of genome does Rhinovirus have?
Non-enveloped
What type of Influenza virus is most common and associated with greatest concern?
Influenza virus A
The Hemagglutinin (HA) protein in Influenza virus is associated with what?
Cell attachment
The Neuraminidase (NA) protein in Influenza virus is associated with what?
Viral budding and release
Which type of Influenze has animal reservoirs?
Type A
Where does transcription and replication of Influenza virus take place?
The nucleus
What are the symptoms of Influenza virus?
Fever, malaise, nonproductive cough, sore throat
What are complications of influenza virus?
Viral pneumonia, bacterial pneumonia, reye syndrome, otitis media
What strains of influenza do vaccines usually contain?
(Attenuated live vaccine) H3N2, H1N1, and Type B strain
What does Tamiflu do?
Blocks release of budding virions
How are adenovirus strains differentiated?
Serotype
What family of virus do adenovirus belong to?
Adenoviridae
How does Adenovirus enter the cell?
Via Coxsackie-adenovirus receptor (CAR) and then moves to the nucleus
What is unique about Adenovirus replication?
Occurs in three phases
What genes are made in the immediate-early phase of Adenovirus replication?
Transcriptional regulators (trying to take over the resources of the cell)
What genes are made in the early phase of Adenovirus replication
DNA replication and post transcriptional events
What genes are made in the late phase of Adenovirus replication?
Take over of cellular mRNA synthesis
Adenovirus needs the cell to be doing what in order to replicate?
The host cell must be replicating
How does Adenovirus promote a cell to be in a replication stage?
E1A inactivates pRb leading to S phase gene expression; E1B inactivates p53 leading to S phase and preventing apoptosis
What are symptoms of Adenovirus respiratory disease?
Common Cold - like nasal congestion, inflammation, cough (serotypes 1, 2, 5, 6); (Serotypes 4 and 7 can result in sever pneumonia in military recruits)
Rhinovirus causes what type of infections?
Mild upper respiratory infections
Why is it difficult to cure rhinovirus?
Over 100 serotypes makes vaccine development impractical
What are symptoms of Rhinovirus?
Common Cold - Red nose, nasal discharge
