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Micro Final > Respiratory Viruses > Flashcards

Respiratory Viruses Flashcards

1
Q

What type of genome does Influenze virus have?

A

SEgmented (-) ssRNA

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2
Q

What type of virion does Influenza virus have?

A

Enveloped

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3
Q

What type of genome does Adenovirus have?

A

dsDNA

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4
Q

What type of virion does Adenovirus have?

A

Non-enveloped

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5
Q

What type of genome does Rhinovirus have?

A

(+)ssRNA

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6
Q

What type of genome does Rhinovirus have?

A

Non-enveloped

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7
Q

What type of Influenza virus is most common and associated with greatest concern?

A

Influenza virus A

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8
Q

The Hemagglutinin (HA) protein in Influenza virus is associated with what?

A

Cell attachment

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9
Q

The Neuraminidase (NA) protein in Influenza virus is associated with what?

A

Viral budding and release

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10
Q

Which type of Influenze has animal reservoirs?

A

Type A

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11
Q

Where does transcription and replication of Influenza virus take place?

A

The nucleus

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12
Q

What are the symptoms of Influenza virus?

A

Fever, malaise, nonproductive cough, sore throat

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13
Q

What are complications of influenza virus?

A

Viral pneumonia, bacterial pneumonia, reye syndrome, otitis media

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14
Q

What strains of influenza do vaccines usually contain?

A

(Attenuated live vaccine) H3N2, H1N1, and Type B strain

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15
Q

What does Tamiflu do?

A

Blocks release of budding virions

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16
Q

How are adenovirus strains differentiated?

A

Serotype

17
Q

What family of virus do adenovirus belong to?

A

Adenoviridae

18
Q

How does Adenovirus enter the cell?

A

Via Coxsackie-adenovirus receptor (CAR) and then moves to the nucleus

19
Q

What is unique about Adenovirus replication?

A

Occurs in three phases

20
Q

What genes are made in the immediate-early phase of Adenovirus replication?

A

Transcriptional regulators (trying to take over the resources of the cell)

21
Q

What genes are made in the early phase of Adenovirus replication

A

DNA replication and post transcriptional events

22
Q

What genes are made in the late phase of Adenovirus replication?

A

Take over of cellular mRNA synthesis

23
Q

Adenovirus needs the cell to be doing what in order to replicate?

A

The host cell must be replicating

24
Q

How does Adenovirus promote a cell to be in a replication stage?

A

E1A inactivates pRb leading to S phase gene expression; E1B inactivates p53 leading to S phase and preventing apoptosis

25
Q

What are symptoms of Adenovirus respiratory disease?

A

Common Cold - like nasal congestion, inflammation, cough (serotypes 1, 2, 5, 6); (Serotypes 4 and 7 can result in sever pneumonia in military recruits)

26
Q

Rhinovirus causes what type of infections?

A

Mild upper respiratory infections

27
Q

Why is it difficult to cure rhinovirus?

A

Over 100 serotypes makes vaccine development impractical

28
Q

What are symptoms of Rhinovirus?

A

Common Cold - Red nose, nasal discharge

Micro Final (13 decks)

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