Respiratory14

Question 1

What are the 2 types of Expectorants?

Answer 1

Guaifenesin (expectorant)

N-acetylcysteine (mucolytic)

Question 2

Guaifnesin.

Answer 2

Expectorant – Thins respiratory secretions

Does NOT suppress cough reflex

Question 3

N-acetylcysteine.

Answer 3

Mucolytic – Loosen mucous plugs in CF patients

*Antidote for Acetaminophen OD

Question 4

What drug is used to treat pulmonary arterial hypertension?

Answer 4

Bosentan

Question 5

What is the MOA of Bosentan?

Answer 5

Competitively antagonized Endothelin-1 receptors -> DEcrease pulmonary vascular Resistance

Question 6

What drug is an antitussive?

Answer 6

Dextromethorphan

Question 7

What is the MOA of Dextromethorphan?

Answer 7

Antagonizes NMDA glutamate receptors

*Synthetic codeine analog – mild opioid effect when used in excess

Question 8

What is give for a Dextromethrophan OD?

Answer 8

Naloxone

Question 9

Pseudoephedrine, Phenylephrine.

• Mechanism
• Uses
• Adverse Effects

Answer 9

• Sympathomimetic a-agonist
  
  • Nonprescription nasal decongestants
• Reduce hyperemia, edema & nasal congestion
• Open obstructed eustachian tubes
• Pseudoephedrine also used as Stimulant

Adverse Effects:

• Hypertension
• CNS stimulation/Anxiety (pseudoephedrine)

Question 10

Methacholine.

• MOA
• Use

Answer 10

Muscarinic receptor Agonist

Asthma challenge test