Respiratory - Pulmonary Hypertension + PTE Flashcards

1
Q

Pulmonary hypertension (PH) refers to

A

elevated pulmonary arterial pressure
Systolic PAP >30mmHg
Mean PAP > 20mmHg
Diastolic PAP >15mmHg

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2
Q

Under normal conditions, pulmonary circulation has very low ____ and_____ compared to systemic circulation

A

resistance and pressure

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3
Q

PAP calculation

A

PAP = (cardiac output x pulmonary vascular resistance) + pulmonary venous pressure

where PVR = (vessel length x viscosity of blood)/radius^4

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4
Q

T/F pulmonary vascular resistance is heavily reliant on the radius of the vessel

A

true (think, its ^4!)

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5
Q

Classifications of PH

A
PH due to pulmonary vascular disease
PH due to left sided heart disease
PH due to chronic pulmonary disease and/or hypoxia
PH due to thrombotic or embolic disease
miscelaneous
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6
Q

T/F: PH is usually secondary to another condition

A

true

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7
Q

Signalment for PH

A

dogs&raquo_space; cats
middle aged to older
small breed > large breeds

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8
Q

Which of the following is not a clinical sign of pulmonary hypertension?
A) cough
B) exertion induced presyncope or syncope
C) tachypnea and dyspnea
D) left sided heart failure

A

D - right sided heart failure

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9
Q

patients with severe PH may have systemic

A

hypotension

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10
Q

A murmur due to _______ may be present

A

tricuspid regurgitation (PMI right apex)

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11
Q
The current non-invasive gold standard test for diagnosis of pulmonary hypertension in small animals is:
A) thoracic radiographs
B) Ultrasound
C) echocardiography
D) blood test
A

C - blood test

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12
Q

A dog comes in presenting with tachypnea, dyspnea, and a cough. The owner mentions the dog has not been able to handle their daily walks and gets tired easily lately. You conduct an echocardiogram and confirm the dog has pulmonary hypertension. What is your next step?

A

Do a minimum database, a heart worm test, and thoracic radiographs to determine an underlying cause of the pulmonary hypertension

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13
Q

What do you expect to see on a thoracic radio graph of a dog with pulmonary hypertension
A) bronchi that are deviated outwards on a VD view due to enlarged LA
B) ventral deviation of trachea
C) right side enlargement
D) decreased sternal contact of the heart

A

C - you’d see right side enlargement, cardiomegaly, dorsal deviation of treatment, increased sternal contact, and bronchi would not be deviated away from each other on VD because L side would not be enlarged

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14
Q

T/F: an echo is useful in diagnosing pulmonary hypertension but is limited in what it can tell us about the disease

A

False, shows us:
tricuspid regurgitation +/- pulmonic regurgitation - can provide estimate of pulmonary pressure
right ventricular hypertrophy and dilation - RV systolic dysfunction is not common but can occur
right atrial dilation, hypertrophy of RV ( tells us pressure overload likely due to pulmonary valve or hypertension)
diastolic flattening of ventricular septum
dilated main pulmonary artery and branches

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15
Q

Modified Bernoulli equation

A

PG = 4 x velocity^2

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16
Q

Which of the following is FALSE regarding the treatment of pulmonary hypertension?
A) treating the underlying cause is imperative
B) Direct treatment of pulmonary arterial hypertension is achieved with pulmonary vasoconstrictor drugs
C) Supplemental oxygen should be included in tx plan for dyspneic patients
D) Most commonly used pulmonary vasodilator drug in small animals is Sildenafil

A

B - direct treatment of pulmonary arterial hypertension is achieved with pulmonary vasodilator drugs

17
Q

Sildenafil

A

phosphodiesterase V inhibitor
most commonly used pulmonary vasodilator drug
used in moderate to severe cases
(Tx pulmonary hypertension)

18
Q

Pimobendan

A

mild pulmonary vasodilatory effects and used in some cases of pulmonary hypertension

19
Q

Prognosis of pulmonary hypertension

A

if underlying cause is treated, prognosis is fair to good
severe = poor long term prognosis, guarded short term
sudden death can occur in severe patients
severe patients may develop R sided CHF
Low out HF also possible

20
Q

What is a PTE?

A

pulmonary thromboembolism

obstruction of pulmonary artery by thrombus that originated in systemic venous circulation (or within RA/RV)

21
Q

Virchow’s triad of thrombus formation

A

hypercoaguability
endothelial injury
blood stais

22
Q

conditions associated with PTE

A

IMHA, protein-losing nephropaty or enteropathy, neoplasia, pancreatitis, diabetes mellitus, hyperadrenocorticism/corticosteroids, sepsis, R sided cardiac disease, HWD, trauma, major surgery

23
Q

T/F: onset of clinical signs of PTE are often chronic

A

False, acute

24
Q

Signs of PTE

A

dyspnea, tachypnea, lethargy, cyanosis, syncope, cough, TR murmur if severe PH develops

25
Q

T/F: thoracic rads always show distinguishing lesions and are helpful diagnosing PTE

A

False, rads may appear completely normal though this itself is helpful to diagnose (bc many diseases with similar presentations would have abnormal rads)

26
Q

Diagnostic tests for PTE

A

CT, angiogram, radionuclide ventilation/perfusion scans
thoracic rads, arterial blood gas, D-Dimers, PT, aPTT, thromboelastography
minimum database and HW test to investigate underlying cause

27
Q

Abnormal PTE rads may show

A

focal interstitial/alveolar infiltrates, lung lobe consolidation
hypo vascular area/lobe is fairly specific for PTE

28
Q

A dog comes into your clinic and presents with a cough and lethargy. You perform a arterial blood gas and see that the dog is hypoxic, has hypocapnia, and increased alveolar-arterial gradient. Thoracic rads show a hypo vascular area on one of the lung lobes. What do you suspect?

A

PTE

29
Q

Why would a arterial blood gas come back hypoxic AND hypocapnic on a PTE patient??

A

because both gases are unable to be exchanged

30
Q

2 goals of PTE treatment?

A

prevent growth of pre-existing thrombi and prevent formation of new thrombi
support resp and CV systems

31
Q

acute treatment of PTE

A

anticoagulant therapy with unfractioned heparin of LMW heparin
supplemental O2
judicious IV fluid therapy to optimize tissue perfusion

32
Q

2 anti platelet drugs

A

clopidogrel and aspirin