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Respiratory pharm Flashcards

1
Q

Chlorpheniramine

A

H1 blocker - 1st generation

Use: Motion sickness, allergies

TOxicity: Sedation, antimuscarinic

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2
Q

Diphenhydramine

A

H1 blocker - 1st generation

Use; Motion sickness, allergies

Toxicity: Sedation, antimuscarinic

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3
Q

Dimenhydrinate

A

H1 blocker - 1st generation

Use: motion sickness, allergies

Toxicity: Sedation, antimuscarinic

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4
Q

Loratadine

A

2nd generation antihistamine

No sedation

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5
Q

Fexofenadine

A

2nd generation antihistamine

No sedation

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6
Q

Cetirizine

A

2nd generation antihistamine

No sedation

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7
Q

Rifampin

A

Vs tuberculosis

Toxicity: red urine, red contact lenses

Potent stimulator of p450

Mech: Blocks RNA synthesis

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8
Q

Isoniazid

A

Blocks mycolic acid synthesis, activated by catalase-peroxidase of mycobacterium, vs TB

Toxicity: Lupus like syndrome

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9
Q

Albuterol

A

Short acting B2 agonist vs acute attack of asthma

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10
Q

Salmeterol

A

Long acting B2 agonist, used as prophylaxis

Toxicity: Tremor, arrythmia

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11
Q

Theophylline

A

Methylxanthine

Mech: Decreases cAMP

Toxicity: Cardiotoxic, neurotoxic, seizures

Antidote to Adenosine

Treatment vs toxicity: Charcoal, B blocker

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12
Q

Ipratropium

A

Muscarinic antagonist

Used in asthma or in COPD

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13
Q

Beclomethasone, fluticasone

A

Inactivate NF-KB to decrease TNF alpha and dec inflammation

Used vs chronic asthma

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14
Q

Montelukast/zafirlukast

A

block leukotriene receptors

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15
Q

Zileuoton

A

Blocks 5-lipoxyngase -> Decrease arachidonic converstion to leukotrienes

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16
Q

Omalizumab

A

Anti IgE antibody

Vs allergic asthma

17
Q

Guaifenesin

A

Thins respiratory secretion

18
Q

N-acetylcysteine

A

Mucolytic

Loosens disulfide bonds of mucous plugs

19
Q

Bosentan

A

Vs pulmonary artery hypertension

Decreases pulmonary vascular resitance

20
Q

Dextromethorphan

A

Vs NMDA glutamate receptors -> decreases cough

Naloxone vs overdose

21
Q

Phenylephrine

A

A agonist -> vs congestion of nose

Toxicity: Hypertension

22
Q

Methacholine

A

ACh agonist used vs asthma testing

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