biochem Flashcards
1
Q
Deficient ornithine transcarbamoylase
A
Ornithine transcarbmolase deficiency
Increased carbomyl phosphate -> Converted to orotic acid used in pyrimidine synthesis
Deficient urea cycle
2
Q
Orotic aciduria
A
Dec orotic acid to UMP -> pyrimidine synth via UMP synthase problem
Findings: Orotic acid in urine, megaloblastic anemia not improved w/ B12 or folate
Tx: Uridine
3
Q
Enzyme inhibited by hydroxyurea
A
ribonucleotide reductase
4
Q
Mechanism of aminoglycosides
A
Bind 30s -> vs initiaion complex and misreading of MRNA
5
Q
Tetracyclines
A
vs 30s, block tRNA entering a site
6
Q
Chloramphenicol
A
50s vs peptidyl transferase
7
Q
Macrolides
A
50s vs release of uncharged tRNA
