immuno pharm

Question 1

Cyclosporine

Answer 1

Inhibits calcineurin, decreasing IL-2 and decreasing T cell activation

Used in transplant rejection suppression

Toxicity: Nephrotoxic, gingival hyperplasia, hyperglycemia, tremor

Question 2

Tacrolimus

Answer 2

Decreases calcineurin and decreases IL-2 -> decreases T cells

Used in organ transplants

Toxicity: Nephrotoxic, hypertension, hyperglycemia

Question 3

Sirolimus

Answer 3

vs mTOR -> Decreases IL-2 T cell proliferation

Used after transplantation alsongside cyclosporine

Toxcity: Hyperlipiedmia, thrombocytopenia, luekopenia

Question 4

Azathioprine

Answer 4

6 mercaptopurine precurosor, decreases nucleic acids

Used vs kidney transplants

Toxicity: bone marrow suppression, toxicity increased with allopurinol

Question 5

Muromonab

Answer 5

Monocloal antibody vs CD3 on T cells, decreases T cell signal transaction

Used vs transplantation

TOxicity: cytokine release, hypersensitivity