pharm Flashcards
Bethanechol
Cholimimetic -> Bethany call me if you want to activate your bowel and bladder
Carbachol
ACh like, vs glaucoma
Pilocarpine
Cholinomimetic, stimulates sweat/tears/saliva, vs glaucoma
Cry drool and sweat on your PILOw
Methacholine
Cholinomimetic, used to test vs asthma, stimulates muscarinic receptors in airway
Neostigmine
ACh esterase inhibitor -> vs myasthenia gravis
Does NOT enter CNS
Pyridostigmine
ACh esterase inhibitor, does not penetrate CNS, long acting vs Myasthenia Gravis
Edrophonium
Short acting ACh esterase inhibitor to test for Myasthenia Gravis
Physostigmine
ACh esterase inhibitor that CROSSES the blood brain barrier
vs atropine overdose
Donezepil
ACh esterase inhibitor vs Alzheimer’s disease
What is the therapy vs Cholinesterase inhibitor poisoning?
Atropine + pralidoxime
Atropine, Tropicamide
Muscarinic antagonist, produces mydriasis
Benztropine
Muscarinic antagonist vs Parkinsons
PARK your mercedes BENZ
Scopolamine
Muscarinic antagonist vs Motion sickness
Ipratropium
Muscarinic antagonist vs COPD/asthma -> I PRAy I can breathe again
Oxybutynin
Muscarinic antagonist, vs Bladder spasm, reduces urgency
Glycopyrrolate
Muscarinic antagonist, decreases airway secretion
Atropine toxicity
Inc. Body temp
Dry and flushed skin
Disorientation
Cycloplegia
similar symptoms found in JIMSON WEED
Epinephrine
Agonist of Alpha and Beta receptors
Used vs anaphylaxis, glaucoma, asthma, hypotension
Norepinephrine
Alpha agonist
B1 agonist!!! not b2!!!!
Used vs hypotension
Isoproterenol
B agonist only!!
Vs torsades de pointes
Dopamine
High dose - alpha agonist
Medium dose - beta agonist
Low dose - D1 agonist
Use: Vs shock and heart failure
Dobutamine
B1 agonist primarily
Vs heart failure or used in cardiac stress testing
Phenylephrine
Alpha agonist only
Vs hypotension, ocular procedures
Albuterol/salmeterol/terbutaline
B2»_space;> B1 agonist
Bronchodilation in ashtma
Ritodrine
B2 agonist vs premature uterine contractions
Amphetamine
Increases release of NE, decreases reuptake
Used vs narcolepsy
Ephedrine
Sympathomimetic, vs nasal congestion
Cocaine
Decreased reuptake of NE
Causes vasoconstriction and anesthesia
DO NOT MIX WITH B BLOCKER -> causes extreme alpha agonist activity and hypertension
What is the effect on heart rate of Norepinephrine?
Decreased heart rate as MAP increases
Clonidine/Methyldopa
Sympathoplegic -> Alpha 2 agonist -> decreases sympathetic outflow
Used in hypertension
Phenoxybenzamine
Alpha blocker -> irreversible
Used vs pheochromocytoma
Leads to orthostatic hypotension and reflex tachycardia
Phentolamine
Reversible alpha blocker
Give to patients on MAO inhibitor who eat foods with tyramine
Prazosin/terazosin
-osin ending -> alpha 1 blocker!!
Vs Hypertension or urinary retention
1st dose: gives orthostatic hypotension!!
Mirtazipine
Alpha 2 blocker
Vs depression -> leads to sedation and increased appetite
What are contraindications to Beta blockers?
Asthma
Diabetes
What B blockers are B1 selective? Which are B1 and B2 (generalized)?
B1 selective -> A-M (Metoprolol)
B1/B2 nonselective -> N-Z
What B blockers are Alpha and Beta blockers?
Carvedilol, Labetalol
What B blockers are partial B agonist?
Pindolol, Acebutalol
Acetaminophen toxicity antidote
N acetylcysteine (inc. glutathione)
Salicylates toxicity antitodte
NaHCO3
Amphetamines tox antidote
NH4Cl
B blocker antidote
Glucagon
Digitalis toxicity antidote
K+, Mg2+
Lead toxicity antidote
Penicillamine, Dimercaprol
Cyanide toxicity antidote
Nitrite + thiosulfate
Ethylene glycol toxicity antidote
Fomepizole
Opioid toxicity antidote
Naloxone
Benzodiazepine toxicity antidote
Flumazenil
TCA toxicity antidote
NaHCO3
Heparin toxicity antidote
Protamiine
Warfarin toxicity antidote
Vitamin K
Theophylline toxicity antidote
B blocker