Respiratory Drugs - CLASSES/MECHANISMS

Question 1

Formoterol

Answer 1

Long-acting beta-2 agonist

Question 2

Diphenhydramine

Answer 2

1st generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 3

Dimenhydrinate

Answer 3

1st generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 4

Albuterol

Answer 4

Short-acting beta-2 agonist

Question 5

Tadalafil

Answer 5

Inhibits PDE-5 - increases cGMP - prolonged vasodilatory effect of NO

Question 6

Tiotropium

Answer 6

Muscarinic antagonist

Question 7

Pseudoephedrine

Answer 7

Alpha-adrenergic agonists: Nasal decongestant

Question 8

Dextromethorphan

Answer 8

Antitussive: Antagonizes NMDA glutamate receptors (synthetic codeine analog)

Question 9

Chlorpheniramine

Answer 9

1st generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 10

Zileuton

Answer 10

5-lipoxygenase pathway inhibitor

Question 11

Bitolterol

Answer 11

Short-acting beta-2 agonist

Question 12

Salmeterol

Answer 12

Long-acting beta-2 agonist

Question 13

Ambrisentan

Answer 13

Competitive antagonist of endothelin-1 receptors - decreases pulmonary vascular resistance

Question 14

N-acetylcysteine

Answer 14

Mucolytic - liqufies mucus in chronic bronchopulmonary diseases (e.g., COPD, CF) by disrupting disulfide bonds

Antidote for acetaminophen OD

Question 15

Sildenafil

Answer 15

Inhibits PDE-5 - increases cGMP - prolonged vasodilatory effect of NO

Question 16

Promethazine

Answer 16

1st generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 17

Pirbuterol

Answer 17

Short-acting beta-2 agonist

Question 18

Methacholine

Answer 18

Nonselective muscarinic receptor (M3) agonist

Question 19

Zafirlukast

Answer 19

Leukotriene receptor (CysLT1) inhibitor

Question 20

Epoprostenol

Answer 20

PGI2 (prostacyclin) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds

Inhibit platelet aggregation

Question 21

Ipratropium

Answer 21

Muscarinic antagonist

Question 22

Bosentan

Answer 22

Competitive antagonist of endothelin-1 receptors - decreases pulmonary vascular resistance

Question 23

Phenylephrine

Answer 23

Alpha-adrenergic agonists: Nasal decongestant

Question 24

Fluticasone

Answer 24

Inhaled corticosteroid

Question 25

Loratadine

Answer 25

2nd generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 26

Treprostinil

Answer 26

PGI2 (prostacyclin) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds Inhibit platelet aggregation

Question 27

Omalizumab

Answer 27

Anti-IgE monoclonal antibody

Question 28

Theophylline

Answer 28

Phosphodiesterase inhibitor - increases cAMP - bronchodilation

Question 29

Iloprost

Answer 29

PGI2 (prostacyclin) with direct vasodilatory effects on pulmonary and systemic arterial vascular beds Inhibit platelet aggregation

Question 30

Desloratadine

Answer 30

2nd generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 31

Hydroxyzine

Answer 31

1st generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 32

Fexofenadine

Answer 32

2nd generation antihistamine: Reversible inhibitor of H1 histamine receptors

Question 33

Guaifenesin

Answer 33

Expectorant - thins respiratory secretions; does not suppress cough

Question 34

Montelukast

Answer 34

Leukotriene receptor (CysLT1) inhibitor

Question 35

Budesonide

Answer 35

Inhaled corticosteroid

Question 36

Cetirizine

Answer 36

2nd generation antihistamine: Reversible inhibitor of H1 histamine receptors