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PHARMACOLOGY > Endocrine/Reproductive Drugs - CLASSES/MECHANISMS > Flashcards

Endocrine/Reproductive Drugs - CLASSES/MECHANISMS Flashcards

1
Q

Histrelin

A

GnRH analog

Pulsatile → agonist

Continuous → antagonist

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2
Q

Flutamide

A

Nonsteroidal competitive androgen receptor inhibitor

Will also decreases testosterone inhibition of GnRH secretion → increase serum LH (counteract by always administering with leuprolide)

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3
Q

Somatrem

A

GH analog

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4
Q

Tolvaptan

A

ADH antagonist at V2 receptor (kidney)

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5
Q

Spironolactone

A

Inhibits:

Steroid binding

17,20 desmolase

17-alpha hydroylase

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6
Q

Alendronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

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7
Q

Levothyroxine

A

Thyroid hormone replacement

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8
Q

Pamidronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

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9
Q

Zoledronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

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10
Q

Nafarelin

A

GnRH analog

Pulsatile → agonist

Continuous → antagonist

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11
Q

Propylthiouracil

A

Inhibit thyroid peroxidase → inhibiting the oxidation of iodide and organification and coupling of iodine → inhibition of thyroid hormone synthesis

Also inhibits 5’deiodinase → decreasing peripheral conversion tof T4 to T3

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12
Q

Goserelin

A

GnRH analog

Pulsatile → agonist

Continuous → antagonist

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13
Q

Cinacalcet

A

Sensitizes calcium-sensing receptor (CaSR) in parathyroid gland to circulating free calcium → decreases PTH

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14
Q

Letrozole

A

Aromatase inhibitor

Decreases estradiol levels

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15
Q

Mestranol

A

Estrogen

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16
Q

Terbutaline

A

Beta-2 agonist → relaxes uterus

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17
Q

Octreotide

A

Somatostatin analog

Inhibits release of many hormones

Decreases GI motility

Vasoconstriction

18
Q

Fludrocortisone

A

Synthetic aldosterone analog with little glucocorticoid effects

19
Q

Conivaptan

A

ADH antagonist at V2 receptor (kidney)

20
Q

Danazol

A

Synthetic androgen receptor agonist → decreasing LH and FSH secretion → decreasing growth of endometrial and breast tissue

Also:

Increases levels of C2 esterase inhibitor (deficiency enzyme in hereditary angioedema) → increasing C4 levels

21
Q

Cabergoline

A

Ergot alkaloids - D2 agonist

Stimulate D2 receptors on lactotropes → increasing DA → inhibiting prolactin release

22
Q

Triiodothyronine

A

Thyroid hormone replacement

23
Q

Leuprolide

A

GnRH analog

Pulsatile → agonist

Continuous → antagonist

24
Q

Ethinyl estradiol

A

Estrogen

25
Q

Somatropin

A

GH analog

26
Q

Exemestane

A

Aromatase inhibitor

Decreases estradiol levels

27
Q

Pegvisomant

A

GH antagonist:

PEGylated analog of GH → blocks action of GH on target tissue → decreasing IGF-1

28
Q

Methimazole

A

Inhibit thyroid peroxidase → inhibiting the oxidation of iodide and organification and coupling of iodine → inhibition of thyroid hormone synthesis

29
Q

Ketoconazole

A

Inhibits several steps in steroid synthesis

30
Q

Anastrozole

A

Aromatase inhibitor

Decreases estradiol levels

31
Q

Minoxidil

A

Direct arteriolar vasodilator

Used for androgenic alopecia (pattern baldness)

Severe refractory hypertension

32
Q

Ritodrine

A

Beta-2 agonist → relaxes uterus

33
Q

Demeclocycline

A

ADH antagonist at V2 receptor (kidney)

34
Q

Finasteride

A

5-alpha reductase inhibitor

Decreases conversion ot testosterone to DHT

35
Q

Oxytocin

A

Stimulates uterine contraction

Stimulates contraction of myeoepithelial cells in breast

36
Q

Diethylstilbestrol (DES)

A

Estrogen

37
Q

Ibandronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

38
Q

Tamsulozin

A

Alpha-1 antagonist

SELECTIVE FOR ALPHA-1A RECEPTORS (found on prostate) vs vascular alpha-1b receptors

39
Q

Risedronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

40
Q

Bromocriptine

A

Ergot alkaloids - D2 agonist

Stimulate D2 receptors on lactotropes → increasing DA → inhibiting prolactin release

41
Q

Etidronate

A

Bisphosphonate

Pyrophosphate analog

Binds hydroxyapatite in bone → inhibiting osteoclast activity

42
Q

Desmopressin acetate

A

ADH analog

PHARMACOLOGY (33 decks)

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