Drug Reactions

Question 1

Coronary vasospasm

Answer 1

Amphetamines
Cocaine
Ergot alkaloids
Sumatriptan

Question 2

SLE-like syndrome

Answer 2

Sulfa drugs
Hydralazine
Isoniazid
Procainamide
Phenytoin
Etanercept

Question 3

Torsades

Answer 3

Antiarrhythmics - class Ia, III
Antibiotics (macrolides)
Antipsychotics (haloperidol)
Antidepressants (TCAs)
Antiemetics (ondansetron)

Question 4

Hypothyroidism

Answer 4

Lithium
Amiodarone
Sulfonamides

Question 5

Drug reaction with eosinophilia and systemic symptoms (DRESS)

Answer 5

Allopurinol
Anticonvulsants (phenytoin, fosphenytoin)
Antibiotics
Sulfa drugs

Question 6

Aplastic anemia

Answer 6

Carbamazepine
Methimazole
Propylthiouracil (PTU)
NSAIDs
Benzene
Chloramphenicol

Question 7

Thrombocytopenia

Answer 7

Heparin

Question 8

Cinchonism (tinnitus, hearing/vision loss, psychosis, cognitive impairment)

Answer 8

Quinidine

Quinine

Question 9

Andrenocortical insufficiency

Answer 9

HPA suppression secondary to glucocorticoid withdrawal

Question 10

Osteoporosis

Answer 10

Corticosteroids
Depot medroxyprogesterone acetate
GnRH agonists
Aromatase inhibitors
Anticonvulsants 
Heparin

Question 11

Hot flashes

Answer 11

Tamoxifen

Clomiphene

Question 12

Hemolysis in G6PD deficiency

Answer 12

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin

Question 13

Pancreatitis

Answer 13

Didanosine
Corticosteroids
Alcohol
Valproate
Azathioprine
Diuretics (Furosemide, HCTZ)

Question 14

Dilated cardiomyopathy

Answer 14

Doxorubicin, Daunorubicin

prevented with dextazoxane

Question 15

Agranulocytosis

Answer 15

Clozapine
Carbamazepine
Propylthiouracil (PTU)
Methimazole
Colchicine
Ganciclovir

Question 16

Megaloblastic anemia

Answer 16

Hydroxyurea
Phenytoin
Methotrexate
Sulfa drugs

Question 17

Parkinson-like syndrome

Answer 17

Antipsychotics
Reserpine
Metoclopramide

Question 18

Thrombotic complications

Answer 18

Combined oral contraceptives
Hormone replacement therapy
SERMs (tamoxifen, raloxifen, clomiphene)

Question 19

Focal to massive hepatic necrosis

Answer 19

Halothane
Amanita phalloides (death cap mushroom)
Valproate
Acetaminophen

Question 20

Direct Coombs-positive hemolytic anemia

Answer 20

Methyldopa

Penicillin

Question 21

Myopathy

Answer 21

Statins
Fibrates
Niacin
Colchicine
Daptomycin
Hydroxychloroquine
Interferon-alpha
Penicillamine
Glucocorticoids

Question 22

Cutaneous flushing

Answer 22

Vancomycin
Adenosine
Niacin
Nitrates
CCBs
Echinocandins (Anidulafungin, Caspofungin, Micafungin)

Question 23

Seizures

Answer 23

Isoniazid (B6 deficiency)
Bupropion
Imipenem + Cilastatin
Tramadol
Enflurane

Question 24

Acute cholestatic hepatitis, jaundice

Answer 24

Erythromycin

Question 25

Photosensitivity

Answer 25

Sulfonamides Amiodarone Tetracyclines 5-FU

Question 26

Tardive dyskinesia

Answer 26

Antipsychotics | Metoclopramide

Question 27

Hepatitis

Answer 27

``` Rifampin Isoniazid Pyrazinamide Statins Fibrates ```

Question 28

Hyperglycemia

Answer 28

``` Tacrolimus Protease inhibitors Niacin HCTZ Corticosteroids ```

Question 29

Fat redistribution

Answer 29

Protease inhibitors | Glucocorticoids

Question 30

Pseudomembranous colitis (C. difficile)

Answer 30

Ampicillin Cephalosporins Clindamycin Fluoroquinolones

Question 31

Tendonitis, tendon rupture, and cartilage damage

Answer 31

Fluoroquinolones

Question 32

Pill-induced esophagitis

Answer 32

``` Bisphosphonates Ferrous sulfate NSAIDs KCl Tetracyclines ```

Question 33

Diarrhea

Answer 33

``` Acamprosate Acarbose Cholinesterase inhibitors Colchicine Erythromycin Ezetimibe Metformin Misoprostol Orlistat Pramlintide Quinidine SSRIs ```

Question 34

Hyperuricemia (gout)

Answer 34

``` Pyrazinamide Thiazides Furosemide Niacin Cyclosporine ```

Question 35

Gingival hyperplasia

Answer 35

Phenytoin CCBs Cyclosporine

Question 36

Stevens-Johnson syndrome

Answer 36

Anti-epileptic drugs (especially lamotrigine) Allopurinol Sulfa drugs Penicillin

Question 37

Gray baby syndrome

Answer 37

Chloramphenicol

Question 38

Diabetes insipidus

Answer 38

Lithium | Demeclocycline

Question 39

SIADH

Answer 39

Carbamazepine Cyclophosphamide SSRIs

Question 40

Teeth discoloration

Answer 40

Tetracyclines