Cholinomimetic Agents

Question 1

Applications: Bethanechol

Answer 1

Post-op ileus
Neurogenic ileus
Urinary retention

Question 2

Applications: Carbachol

Answer 2

Constricts pupil and relives intraocular pressure in open-angle glaucoma

Question 3

Applications: Methacholine

Answer 3

Challenge test for diagnosis of asthma

Question 4

Applications: Pilocarpine

Answer 4

Potent stimulator of sweat, tears, saliva
Open-angle and closed-angle glaucoma
Sjogren syndrome - xerostomia

Question 5

Applications: Galantamine

Answer 5

Alzheimer disease

Question 6

Applications: Donepezil

Answer 6

Alzheimer disease

Question 7

Applications: Rivastigmine

Answer 7

Alzheimer disease

Question 8

Applications: Edrophonium

Answer 8

Historically used to diagnose MG

Replaced by anti-AChR Ab test

Question 9

Applications: Neostigmine

Answer 9

Post-op and neurogenic ileus
Urinary retention
MG
Reversal of neuromuscular junction blockade (post-op)

Question 10

Applications: Physostigmine

Answer 10

Antidote for anticholinergic toxicity (atropine)

Crosses BBB

Question 11

Applications: Pyridostigmine

Answer 11

MG (long-acting)

Question 12

Treatment: Anticholinesterase poisoning

Answer 12

Atropine (antimuscarinic)

Pralidoxime (regenerates AChE if given early)