GI DRUGS - CLASSES/MECHANISMS Flashcards
Cimetidine
H2 blocker: Reversible block of histamine H2-receptors → decreased H+ secretion by parietal cells
Ranitidine
H2 blocker: Reversible block of histamine H2-receptors → decreased H+ secretion by parietal cells
Famotidine
H2 blocker: Reversible block of histamine H2-receptors → decreased H+ secretion by parietal cells
Nizatidine
H2 blocker: Reversible block of histamine H2-receptors → decreased H+ secretion by parietal cells
Omeprazole
PPI: Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Lansoprazole
PPI: Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Esomeprazole
PPI: Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Pantoprazole
PPI: Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Dexlansoprazole
PPI: Irreversibly inhibits H+/K+ ATPase in stomach parietal cells
Aluminum hydroxide
Antacid
Calcium carbonate
Antacid
Magnesium hydroxide
Antacid
Osmotic laxative: Provides osmotic load to draw water into GI lumen
Bismuth
Bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer
Require acidic environment
Sucralfate
Bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer
Require acidic environment
Misoprostol
PGE1 analog: Increase production and secretion of gastric mucous barrier, decrease acid production