Respiratory Diseases Flashcards
What are the 3 enzootic bacterial “Category A” Agents?
Bacillus anthracis
Yersinia pestis
Francisella tularensis
What is so dangerous about the Category A agents?
Aerosol potential makes them potential bioweapons.
What are 3 main species affected by Francisella tularensis?
Humans
Domestic cats
Sheep
What animals are the long-term reservoir of Francisella tularensis? (2 things)
Rodents and lagamorphs
How is Francisella tularensis transmitted? (3 points)
Sheep: tick-borne
Cats: eating infected rodents
Humans: ticks or direct contact with animals/carcasses
What is the primary cycle of Yersinia pestis?
Rodent - flea - rodent
What is the vetor of Yersinia pestis?
Xenopsylla cheopis
What domestic animal is susceptible to Yersinia pestis?
Cats
How do people contract Yersinia pestis? (3 ways)
Flea bite
Aerosol
Directly from infected animal blood or abscesses
What are the clinical signs of plague and tularemia in cats?
Fever, lethargy, anorexia, sepsis
Lymphadenopathy
Are the signs of plague and tularemia similar in cats and people?
Yes
What must we remember when treating cats affected with either plague or tularemia?
L.N. aspirates are highly infection, use PPE and isolate
What must veterinarians be careful of with regards to Bacillus anthracis?
Aerosol or percutaneous exposure to blood from infected animals = BAD!
What happens in most cases of anthrax?
Spores enter host and germinate causing sepsis, endotoxins create massive edema, shock, and death (DIC)
What species are the reservoir for Hantavirus?
Rodents (typically asymptomatic)
What is the distribution of Hantavirus?
Worldwide
How is Hantavirus transmitted usually?
Primarily aerosol via inhalation of viruses in urine or feces.
What is the secondary route of transmission for Hantavirus?
Via bite
What are the clinical signs in people of New World Hantavirus?
Fever, chills, myalgia, headache, increased vascular permeability in the lungs
What is the frequency of fatality of New World hantavirus?
~40%
What are the clinical symptoms of Old World Hantavirus?
Petichial hemorrhage, renal damage, cardiovascular shock.
What is the frequency of fatality of Old World Hantavirus?
~15%
What is a major risk factor for contracting hantavirus?
Rodent contact
How can risk of hantavirus be reduced?
Reduce human exposure
What are pulmonary fungal infections?
Infections from spores that are aerosolized or inhaled.
What are the two major soil fungi that cause pulmonary infection?
Blastomyces and Coccidiodes