Respiratory: Control of Respiration Flashcards

1
Q

Where is the major rhythm generatory for resp

A

Medulla

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2
Q

What network of neurones generate the breathing rhythm?

A

Pre-botzinger complex

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3
Q

Where is this complex located

A

the upper end of the medulla

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4
Q

What gives rise to inspiration

A

Dorsal respiratory group of neurones fire.
Leads to contraction of inspiratory muscle= INSPIRATION
When firing stops= passive expiration

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5
Q

What gives rise to active expiration

A

Increased firing of dorsal neurones excites a second group of ventral neurones which excite internal intercostal muscles and illicit forceful expiration

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6
Q

How can the rhythm be modified?

A

By neurones in the pons

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7
Q

Explain the mechanism of modifying rhythm in the pons pneumotaxic centre

A

The pneumotaxic centre is stimulated when dorsal respiratory neurones fire.
Stimulation terminates inspiration.

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8
Q

What would happen without the pneumotaxic centre

A

breathing would be prolonged inspiratory gasps with brief expiration known as APEUNSIS

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9
Q

Explain the rhtym modifyin by the apneustic centre

A

impulses from theses neurones excite inspiratory area of medulla and prolong inspiration

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10
Q

Name examples of involuntary modifications of breathing

A

Pulmonary stretch receptors refelx
Joint receptors reflex
Stimulation of resp centre by temp, adrenalin or impulses from cerebral cortex
cough reflex

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11
Q

Explain pulmonary stretch receptors

A

Activated during inspiration- inhibits inspiration

Only fire at large tidal volumes

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12
Q

Describe the joint receptor reflex

A

Impulses from moving limbs reflexly increased breathing

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13
Q

What factors may increase ventilation during exercise

A
Body movement
Adrenaline
Impulses from cerebral cortex
Increased body temp
Accumulation fo COs and H plus ions
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14
Q

Explain the cough reflex

A

Activated by irritation of the airways or tight airways eg asthma
Afferent discharge stimulates short intake of breath followed by closure of the larynx, the contraction of abdominal muscles and opening of the larynx and there is an expulsion of air at high speed

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15
Q

Where is the cough reflex controlled

A

the medulla

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16
Q

What senses the values of gas tensions

A

chemoreceptros

17
Q

what do your peripheral chemoreceptors sense

A

tension of oxygen and carbon dioxide, and the pH of the blood

18
Q

Where are central chemoreceptors located

A

surface of medulla

19
Q

What do central chemoreceptors respond to

A

hydrogen ions of cerebrospinal fluid

20
Q

Why is CSF less buffered than blood?

A

Less protein

21
Q

What happens to ventilation as you become hypercapnic

A

Ventilate more

22
Q

What happens in mild to moderate hypoxia

A

Increased ventilation (peripheral chemoreceptors0

23
Q

What happens in sever hypoxia

A

Neurons are depressed- decreased ventilation

24
Q

What mediates the hypoxic drive

A

peripheral chemoreceptors

25
Q

Explain hypoxic drive

A

Stimulates when PO2 falls below 8- it is important in patients with COPD and at high altitudes

26
Q

What causes hypoxia at high altitudes

A

decrease partial pressur of oxygen

27
Q

How does you body respond to this

A

hyperventilation and increase cardiac output

28
Q

Give the chronic adaptations to high altitude

A
Increaced RBC production
Increased 2,3 BPG
Increase capillaries
Increased mitochondria
Kidneys conserve acid - decrease in arterial pH
29
Q

What is the hydrogen ion drive or respiration

A

Via peripheral chemoreceptors- stimulated in response to H plus causes hyperventilation to try to eliminate more carbon dioxide from the body