Resp Microbiology Flashcards
what causes whooping cough?
bordatella pertussis
what is the treatment for whooping cough?
erythromycin
what are the causes of exacerbation of COPD?
haemophilus
strep pneumonia
adenovirus
rhinovirus
what is the treatment for exacerbation of COPD?
1st line - amoxicillin (+/- steroid)
2nd line - doxycycline
who is mycoplasma pneumonia most likely to infect?
children and elderly
mycoplasma pneumonia comes in waves of how many years?
4 years
who is chlamydia psittici seen in?
people with birds
what does chlamydia psittici present with?
mucoid sputum
what is the treatment for chlamydia psittici?
1st doxycycline
2nd erythromycin
who is coxeilla seen in?
farmers - spread from sheep and goats
what can coxiella cause?
culture negative endocardites
when is legionella seen?
people who have been abroad
in contact with contaminated water, air con systems or swimming pools
how does legionella present?
dry cough, flu like symptoms, GI upset
what biochemistry is seen with legionella?
hyponatraemia
what investigation is done for legionella?
urine antigen positive
what is the treatment for legionella?
levofloxacin or clarithromycin + rifampicin
what antibiotic does mycoplasma pneumonia, chlamydia psittici, coxeilla and legionella all respond too?
clarithromycin
what sputum is seen with strep pneumonia?
red rusty sputum
what can cause staph aureus pneumonia?
SAB
endocarditis
develops secondary to viral influenza
how does staph aureus pneumonia present?
bilateral caveatting pneumonia
how is klebsiella pneumonia caused?
aspiration as part of normal flora
who is at risk of klebsiella pneumonia?
alcoholics
elderly
diabetics
neuro-muscular disease
how does klebsiella pneumonia present?
red jelly sputum
causes lung abscesses and empyema
who is at risk of pneumocystis jiroveci?
immunocompromised
HIV
how is pneumocystis jiroveci treated?
co-trimoxazole (active or prophylactic)
who is at risk of pseudomonas?
CF and bronchiectasis
how do you treat pseudomonas pneumonia?
ciprofloxacin
what is the CURB65 score?
confusion >7 urea >7 RR >30 BP <90 S, <60 D >65 each gets a point
what are the 3 categories for CURB65?
mild = 0 moderate = 1/2 (2 or more admit) severe = >3
what is the 1st line treatment for mild/moderate CAP?
oral amoxicillin 5 days
what is the 2nd line/allergic treatment for mild/moderate CAP?
doxycycline 5 days
what is the treatment for mild/moderate CAP when NBM?
IV clarithromycin
what is the 1st line treatment for severe CAP?
IV Co-amox and doxycycline 7 days
what is the 2nd line treatment for severe CAP?
levofloxacin and doxycycline
what is the 1st line treatment for severe CAP in ITU?
IV co amox and IV clarithromycin 7-10 days
what is the 2nd line treatment for severe CAP in ITU?
levofloxacin and clarithrymycin
what is the definition of hospital acquired pneumonia?
develops 48 hours or more after admission
what is the 1st line treatment for non-severe HAP?
oral amox and met
what is the 2nd line treatment for non-severe HAP?
co-trimoxazole and met
what is the 1st line treatment for severe HAP?
IV amox, met and gent 7 days
what it is the 2nd line treatment for severe HAP?
IV co-trimoxazole, met and gent
what can broad spectrum antibiotics cause?
c.diff
MRSA
what lobes are most affected by aspiration pneumonia?
right middle and lower lobes