hypertension Flashcards

1
Q

what is stage 1 hypertension?

A

clinical: >= 140/90
APBM: >= 135/85

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2
Q

what is stage 2 hypertension?

A

clinical: >= 160/100
APBM: >= 150/95

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3
Q

what is stage 3/severe hypertension?

A

=> 180 systolic

=> 120 diastolic

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4
Q

what is isolated systolic hypertension?

A

systolic => 160

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5
Q

what is hypertensive crisis?

A

=> 200/120 + papilloedema

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6
Q

when should secondary disease be considered as the cause for hypertension?

A

less than 40 years old
resistant BP
positive findings on U+Es

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7
Q

when should treatment be offered?

A

for stage 2 and above

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8
Q

when should treatment be offered for stage 1?

A
<80 years old 
has diabetes
renal disease
end organ damage
cardiovascular disease
10 years cardiovascular risk >20%
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9
Q

what is the treatment for a patient <55 years or T2DM ?

A

step 1: ACE inhibitor
step 2 : A + CCB or A + thiazide diuretic
step 3: A + B + C

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10
Q

what it the treatment for a patient =>55 years or Afro-Caribbean?

A

step 1: CCB
step 2: C + ACE inhibitor or C + thiazide diuretic
step 3: A+ B + C

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11
Q

what is step 4 for hypertension management?

A

step 4: K <= 4.5 spironolactone

K >4.5 alpha blocker or beta blocker

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12
Q

what treatment should hypertensive patients with T1DM be started on? why?

A

ACE inhibitor

due to renal protective effect

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13
Q

when can beta blockers be used first line?

A

in younger patients who:
can’t tolerate ACE
may become pregnant
have sympathetic drive signs - sweating, palpitations

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14
Q

what is a hypertensive emergency?

A

BP >200/120 with evidence of end organ failure

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15
Q

what causes a hypertensive emergency?

A
thyroid storm 
phaeocromocytoma 
pre-eclampsia
head injury 
drugs
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16
Q

what is the management for hypertensive emergency?

A

no end organ damage: oral treatment
end organ damage (especially CCF or encephalopathy):
- labetalol if no LV failure
- furosemide + hydralazine if LV failure

17
Q

what is the aim of management in hypertensive crisis?

A

not a sudden drop in BP, slowly brought down over 24 hours

can cause stroke or dissection

18
Q

if BP is >= 180/20, when should they be admitted for specialist treatment?

A

signs of retinal haemorrhage or papilloedema

life threatening symptoms - new onset confusion, chest pain, signs of heart failure, acute kidney injury

19
Q

if BP >=180/20 but no signs of concern or life threatening symptoms, what should the next step be?

A

urgent investigation of end-organ damage

  • if found, start treatment immediately
  • if not found, repeat clinic blood pressure within 7 days
20
Q

when does ABPM take measurement?

A

least 2 measurements per hour during person’s usual waking hours (between 8-10)
use average of 14 values

21
Q

how do you record BP using home blood pressure monitoring?

A
  • 2 consecutive readings, 1 min apart with patient seated
  • twice daily, ideally morning and evening
  • at least 4 days, ideally 7
  • discard first day measurement and use average of remaining
22
Q

what is the target BP for patient <80 years?

A

clinic - 140/90

ABPM - 135/85

23
Q

what is the target BP for patient >80 years?

A

clinic - 150/90

ABPM - 145/85

24
Q

what are ACE inhibitors mechanism of action?

A

stop angiotensin I conversion to angiotensin II

25
what are the common side effects of ACE inhibitors?
cough hyperkalaemia angioedema
26
when must ACE inhibitors be avoided?
in pregnant woman
27
what must be checked in a patient on an ACE inhibitor?
renal function must be checked 2-3 weeks after starting due to risk of worsening renal function in patients with renovascular disease
28
what is the mechanism of action of CCB?
block voltage gated calcium channels | -relaxing vascular smooth muscle and force of myocardial contraction
29
what are the common side effects of CCB?
flushing ankle swelling headache
30
what is the mechanism of action of thiazide diuretics?
inhibit sodium absorption at the beginning of the distal convoluted tubule
31
what are the side effects of thiazide diuretics?
hypokalaemia hyponatraemia dehydration
32
what is the mechanism of action of angiotensin II receptor blockers?
block effect of angiotensin II at the AT1 receptor
33
what are the side effects of angiotensin II receptor blockers?
hyperkalaemia
34
when are angiotensin II receptor blockers most commonly used?
when a patient can't tolerate an ACE inhibitor, most commonly due to cough