Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

FINALS > DERMATOLOGY > Flashcards

DERMATOLOGY Flashcards

1
Q

what does hypertrichosis mean?

A

generalised excess hair in no particular patter

androgen independent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what skin condition produces antibodies against hemi-desmosome proteins?

A

bullous pemphigoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

elderly patient with erythematous plaques 1 year prior to formation of blisters on trunk and proximal limbs
what is it?

A

bullous pemphigoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

is bullous pemphigoid Nikolysky sign negative or positive?

A

negative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what would you see on immunofluorescence of bullous pemphigoid?

A

linear IgG and complement along basement membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what skin condition produces antibodies against desmogelin 3?

A

pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is acantholysis? what skin condition is it seen in?

A

separation of individual keratinocytes

seen in pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

middle aged patient with multiple fragile blisters on scalp, face and axilla and also within the mouth and conjunctivae
what is it?

A

pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

is pemphigus vulgaris Nikolsky sign negative or positive?

A

positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is seen on immunofluorescence in pemphigus vulgaris?

A

chicken wire deposition of IgG within the dermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what skin condition produces antibodies against TTG? what other condition is this implicated in?

A

dermatitis herpetiformis

coeliac disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is seen on immunofluorescence in dermatitis herpetiformis?

A

granular deposits of IgA within papillae of epidermis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is hyperkeratosis?

A

thickening of keratin layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is parakeratosis?

A

retention of nuclei in corneocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what skin condition are hyperkeratosis and parakeratosis part of?

A

psoriasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what type of T cells are involved in psoriasis and what do they do?

A

type 1 help T cells stimulate keratinocyte proliferation

17
Q

what histological changes are seen in psoriasis

A

hyperkeratotic stratum corneum with parakeratosis
absence of granular layer
thickening of prickle cell layer
neutrophil filled abscesses in stratum corneum
large dilated papillary blood vessels

18
Q

what is Auspitz sign in chronic plaque psoriasis

A

removing scale causes pin point bleeding

19
Q

what is Koebner phenomenon in psoriasis

A

plaques of psoriasis, similar to chronic plaque disease, develop on trauma site 2-6 weeks after trauma

20
Q

adolescent with scaly erthytematous plaques in tear drop shape on trunk, had cold week before
what is it?

A

guttate psoriasis

21
Q

elderly patient with erythematous glazed plaques on groin, axilla and under breast
what is it?

A

flexural psoriasis

22
Q

how is flexural psoriasis different to other types of psoriasis

A

no scale

23
Q

what signs are seen on psoriatic nail disease

A

pitting, onycholysis, sublingual hyperkeratosis, dystrophy, oil drop lesions

24
Q

what is the first line topical therapy for psoriasis?

A

vit D analogues

calciptriol/calcitriol

25
Q

how is dithranol used in psoriasis?

A

used in short contact regimens for stable chronic plaque disease

26
Q

what disadvantage does dithranol have?

A

it burns and stains normal skin

27
Q

what type of psoriasis are steroids used to treat?

A

flexural disease and palmar plantar disease

28
Q

when is salicylate used in psoriasis?

A

to break down particularly hyperkeratotic skin

29
Q

what type of psoriasis is phototherapy a first first line treatment for?

A

guttate psoriasis

30
Q

what are the side effects of photodynamic therapy?

A

sunburn reaction, conjunctivitis, exacerbation of HSV infection

31
Q

when would systemic therapy be used in psoriasis and what would be used?

A

severe or non responsive disease

methotrexate, ciclosporin, retinoids

32
Q

what are some of the histological findings of dermatitis

A 
spongiosis 
acanthosis
hyperkeratosis
dilated blood vessels
esoinophillic infiltration
33
Q

what gene mutation contributes to atopic dermatitis?

A

fillagrin

34
Q

what is the diagnostic criteria for atopic dermatitis?

A 
itch + 3 or more of:
visible flexure rash
history of flexural rash
personal history of atopy
dry skin in the part year 
onset before the age of 2
35
Q

what is the name of the viral infection that in a patient with dermatitis is a medical emergency?

A

eczema herpeticum

36
Q

what treatment should everyone with atopic eczema have?

A

emollients

37
Q

what should be given to someone with atopic dermatitis for itch?

A

ant-histamines

38
Q

what should be given to someone with a flare up of dermatitis?

A

topical steroids

FINALS (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions