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The Holy Grail (Drugs) > Resp Drugs > Flashcards

Resp Drugs Flashcards

1
Q

Side effects of TB drugs

A

Rifampicin: Orange tears and urine

Isoniazid: Peripheral Neuropathy

Pyrazinamide: Gout and joint pain

Ethambutol: Optic neuritis

All give hepatotoxicity

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2
Q

Give examples of SABAs

A

Salbutamol

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3
Q

Side effects of Beta-agonists

A

Tremors
Tachycardia
Anxiety
Headaches

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4
Q

Give examples of Corticosteroids

A

Beclometasone (inhaled)

Prednisolone (oral)

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5
Q

Side effects of ICS

A

Dysphonia

Oropharyngeal candidiasis

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6
Q

Give examples of Muscarinic-antagonists

A

Short acting: Ipratropium

Long acting: Tiotropium

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7
Q

Side effects of Muscarinic-antagonists

A 
Dry mouth
Flu-like cough
Sore throat
Headaches
Backaches 
Glaucoma
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8
Q

Give examples of Methylxanthines

A

Theophylline

Aminophylline

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9
Q

Side effects of Methylxanthines

A 
Nausea
Vomiting
Abdominal discomfort
Headaches
Convulsions (at toxic levels)
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10
Q

Give examples of CysLT Receptor Antagonists

A

Montelukast

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11
Q

Side effects of CysLT Receptor Antagonists

A

GI disturbances
Headaches
Sleep disturbances

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12
Q

Give examples of Mucolytics

A

Carbocisteine

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13
Q

Side effects of Mucolytics

A

Diarrhoea
Nausea
GI disturbances

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14
Q

Give examples of Cromones

A

Sodium cromoglicate

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15
Q

MoA of Cromones

A

Mast cell inhibitors and stabilisers

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16
Q

MoA of Xanthines

A
  • Blocks adenosine receptors

- Competitive inhibitor for phosphodiesterase

17
Q

MoA of Muscarinic-antagonists

A

Ipratropium- Inhibits M1, M2, and M3 receptors

Tiotropium - Inhibits M3 receptors

18
Q

MoA of CysLT Receptor Antagonists

A

Blocks the effects of leukotrienes

19
Q

MoA of Corticosteroids

A
  • Reduce mast cells, macrophages, eosinophils and T cells

- Stimulate B2 receptors to a certain extent

20
Q

MoA of H1 Receptor Antagonists

A

Reduces the effects of histamine released from mast cells

21
Q

Give examples of H1 Receptor Antagonists

A

Loratidine, fexofenadine, cetirizine

22
Q

Effect of CysLT Receptor Antagonists

A

Reduce inflammation

23
Q

Effect of Muscarinic-antagonists

A
  • Relax ASM

- Inhibit mucus production

24
Q

Effect of Methylxanthines

A
  • Relax ASM

- Reduce inflammation

25
Q

MoA of Mucolytics

A

Reduce sputum viscosity

26
Q

Effect of Mucolytics

A
  • Reduce sputum viscosity
  • Make sputum easier to cough up
  • Reduced COPD exacerbations
27
Q

Effect of Cromones

A

Reduce inflammation

28
Q

Effect of Corticosteroids

A

Decrease inflammation

29
Q

MoA of Beta-2-adrenoceptor Agonists

A

Stimulate B2 receptors

30
Q

Effect of Beta-2-adrenoceptor Agonists

A
  • Relax ASM (bronchodilate)
  • Vasodilate
  • Reduce inflammation
  • Increase mucus clearance

The Holy Grail (Drugs) (15 decks)

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