Resp Drugs Flashcards
Side effects of TB drugs
Rifampicin: Orange tears and urine
Isoniazid: Peripheral Neuropathy
Pyrazinamide: Gout and joint pain
Ethambutol: Optic neuritis
All give hepatotoxicity
Give examples of SABAs
Salbutamol
Side effects of Beta-agonists
Tremors
Tachycardia
Anxiety
Headaches
Give examples of Corticosteroids
Beclometasone (inhaled)
Prednisolone (oral)
Side effects of ICS
Dysphonia
Oropharyngeal candidiasis
Give examples of Muscarinic-antagonists
Short acting: Ipratropium
Long acting: Tiotropium
Side effects of Muscarinic-antagonists
Dry mouth Flu-like cough Sore throat Headaches Backaches Glaucoma
Give examples of Methylxanthines
Theophylline
Aminophylline
Side effects of Methylxanthines
Nausea Vomiting Abdominal discomfort Headaches Convulsions (at toxic levels)
Give examples of CysLT Receptor Antagonists
Montelukast
Side effects of CysLT Receptor Antagonists
GI disturbances
Headaches
Sleep disturbances
Give examples of Mucolytics
Carbocisteine
Side effects of Mucolytics
Diarrhoea
Nausea
GI disturbances
Give examples of Cromones
Sodium cromoglicate
MoA of Cromones
Mast cell inhibitors and stabilisers
MoA of Xanthines
- Blocks adenosine receptors
- Competitive inhibitor for phosphodiesterase
MoA of Muscarinic-antagonists
Ipratropium- Inhibits M1, M2, and M3 receptors
Tiotropium - Inhibits M3 receptors
MoA of CysLT Receptor Antagonists
Blocks the effects of leukotrienes
MoA of Corticosteroids
- Reduce mast cells, macrophages, eosinophils and T cells
- Stimulate B2 receptors to a certain extent
MoA of H1 Receptor Antagonists
Reduces the effects of histamine released from mast cells
Give examples of H1 Receptor Antagonists
Loratidine, fexofenadine, cetirizine
Effect of CysLT Receptor Antagonists
Reduce inflammation
Effect of Muscarinic-antagonists
- Relax ASM
- Inhibit mucus production
Effect of Methylxanthines
- Relax ASM
- Reduce inflammation
