Child Health Drugs

Question 1

What is the function of Orlistat

Answer 1

Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake.

Question 2

Whats the MoA of Orlistat

Answer 2

Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged. Only trace amounts of orlistat are absorbed systemically; the primary effect is local lipase inhibition within the GI tract after an oral dose. The primary route of elimination is through the feces.

Question 3

Name a Lipase Inhibitor

Answer 3

Orlistat

Question 4

Name side effects of Orlistat

Answer 4

GI problems (steatorrhea etc)

Question 5

Name contraindications for Orlistat

Answer 5

Pregnancy / breastfeeding

Question 6

Name some Nucleoside analog reverse-transcriptase inhibitors (NRTIs)

Answer 6

Abacavir and lamivudine

Question 7

What is the MoA of NRTIs

Answer 7

They inhibit viral replication

Question 8

Name a Non-nucleoside reverse transcriptase inhibitor (NNRTI)

Answer 8

efavirenz

Question 9

MoA of efavirenz

Answer 9

works by blocking the function of reverse transcriptase

Question 10

Name types of antiretrovirals

Answer 10

NRTIs, NNRTIs and protease inhibitors

Question 11

Name some protease inhibitors

Answer 11

Lopinavir and ritonavir

Question 12

The combination of Lopinavir and ritonavir is known as

Answer 12

HAART (Highly active antiretroviral therapy)

Question 13

MoA of protease inhibitors

Answer 13

Inhibit a particular liver enzyme that normally metabolizes protease inhibitors

Question 14

MoA of Artemisinin-based combination therapy

Answer 14

Works by attacking multiple parasite proteins

Question 15

MoA of Artesunate

Answer 15

It causes malarial protein damage