Resp - Bordetella Pertussis (whooping cough)

Question 1

Morphology

Answer 1

Gram negative coccobacilli

Aerobe

Question 2

Classification/Diagnosis

Answer 2

Fluorescent antibody test, culture, PCR

Question 3

Pathology

Answer 3

Pertussis toxin (ADP-ribosylating activity on G proteins, increases cAMP, promotes respiratory secretions and reduces neutrophil activity)
adenylate cyclase toxin, tracheal cytotoxin

Question 4

Epidemiology

Answer 4

highly contagious through person to person spread

Question 5

Diseases/Symptoms

Answer 5

catarrhal stage, then paroxysmal stage, then convalescent stage (100-day cough)

complications with infants with high morbidity and mortality

Question 6

Treatments/Vaccinations

Answer 6

Erythromycin or other macrolides
prohpylaxis for close contacts with infected

DTaP vaccine