GI (diarrheal) - Salmonella Enterica, bongori

Question 1

Morphology

Answer 1

Gram negative rods

facultative anaerobe

Question 2

Classification/Diagnosis

Answer 2

Oxidase negative
motile
non-lactose fermenter
<2500 serotypes
test by stool culture

Question 3

Pathology

Answer 3

Crosses M cells
Causes apoptosis of macrophages
modifies vacuoles to support survival
Invades epithelial cells basolaterally/disseminates systemically
Enters epithelial cells directly or through dendritic cells
large infectious dose required

Question 4

Epidemiology

Answer 4

Either 1st or 2nd most common enteropathogen in US

Typhoidal and non-typhoidal strains transmitted through fecal-oral route

common cause is contaminated poultry, eggs, raw milk, dirty water

Question 5

Diseases/Symptoms

Answer 5

gastroenteritis within 1-3 days
enteric fever, bacteremia, endovascular infection, osteomyelitis, abscess

typhoid fever (fever, bacteremia, belly pain, rose spots, hepatosplenomegaly, GI bleeding, peritonitis)

Question 6

Treatment/Vaccination

Answer 6

Rehydration