GI (diarrheal) - Shigella Dysenteriae (flexneri, boydii, sonnei)

Question 1

Morphology

Answer 1

Gram Negative Rods

Facultative Anaerobe

Question 2

Classification/Diagnosis

Answer 2

Oxidase Negative
non-motile
non-lactose fermenter (does not ferment lactose)
test by stool culture

Question 3

Pathology

Answer 3

Crosses M cells of peyer’s patches
Causes apoptosis of macrophages
cell-to-cell spread using actin
low infectious dose

human-to-human spread

Question 4

Epidemiology

Answer 4

3rd most common enteropathogen in US
mostly S. sonnei
higher risk in day care centers and crowded areas

Question 5

Diseases/Symptoms

Answer 5

abdominal cramps
bloody, mucoid diarrhea
high fever
vomiting within 1-3 days

Question 6

Treatment/Vaccinations

Answer 6

fluoroquinalone (if not getting better)