STD - Neisseria Gonorrhoeae

Question 1

Morphology

Answer 1

Gram negative diplocci

Question 2

Classification/Diagnosis

Answer 2

In men - test by gram stain of urethral discharge
Thayer-martin media

In both PCR, nucleic acid amplification tests

Question 3

Pathology

Answer 3

Attaches to mucosal cells via pili and Opa protein
Infects subepithelial space
lipooligosacchride stimulates inflammatory response
Por protein evades destruction by phagolysosome

Question 4

Epidemiology

Answer 4

Direct mucosal contact with infected membranous fluids

6x-7x higher prevalence in adolescents

Question 5

Diseases/Symptoms

Answer 5

In men - urethritis (dysuria, discharge, burning) and epididymitis (pain, swelling erythema of scrotum)
In women - mucopurulent cervitis (discharge, dysaperunia, bleeding, dysuria, pain)
Pelvic inflammatory disease (tubo-ovarian abscess, perinonitis, ectopic pregnancy)
dysuria-pyuria, fizhugh-curtis syndrome
In both - conunctivitis, anorectal infection, pharyngitis, sequelae of disseminated gonococcal infection (DGI, joint lesions, arthritis), Reiter’s syndrome (arthritis, conjunctivitis, urethritis, skin lesions)

Question 6

Treatment/Vaccinations

Answer 6

Single-dose ceftriaxone, other cephalosporins

Resistance is increasing - spectinomycin for those allergic, treat for chlamydia if not ruled out

Screening is essential