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Top 300 Medications > Reproductive Health > Flashcards

Reproductive Health Flashcards

1
Q

Brand

Conjugated Estrogen

A

Premarin

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2
Q

Brand

Estradiol Oral

A

Estrace

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3
Q

Brand

Estradiol transdermal patch

A
  • Alora
  • Climara
  • Minivelle
  • Menostar
  • Vivelle-DOT
  • Estraderm
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4
Q

Indication

Conjugated Estrogens

A
  • Abnormal uterine bleeding
  • Breast Cancer
  • Postmenopausal osteoporosis prevention
  • Amenorrhea due to hypoestrogenism(secondary)
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5
Q

MOA

Conjugated Estrogens

A
  • The estrogen replaces the estrogens produced by the body responsible for the development and maintainance of the fame reproductive system and secondary sex characteristics.
  • Responsible for modulation of gonadotropins(luetenizing hormone and follicle stimulating hormone) through negative feedback
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6
Q

Major contraindications

Conjugated Estrogens

A
  • Angioedema or anaphylactic reaction to estrogens or any component of the formualtion
  • Undiagnosed abnormal genital bleeding
  • DVT or PE
  • Breast cancer
  • Estrogen dependent tumor
  • Hepatic impairment
  • Anitrhombic deficiency
  • Thrombophilic disorders
  • Pregnancy
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7
Q

Black box warnings

Cnnjugated Estrogens

A
  • Endometrial cancer
  • Breat cancer
  • Cardiovascular disease
  • Dementia
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8
Q

Adverse reactions

Conjugated Estrogens

A
  • > 10%:Weight change, headache,migraine,depression,disorder of menstruation, breast pain
  • 1-10%: Edema,vasodilation,abdominal pain,hirtuism, diarrhea,nausea,stomach cramps, vomitting,backache
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9
Q

Serious ADRs

Conjugated estrogens

A
  • Heart disease
  • HTN
  • MI
  • Breast cancer
  • Diabetes mellitus
  • Hypercalcemia
  • Venous thromboembolism
  • Anaphylaxis
  • Cerebrovascular accident
  • Cervical cancer
  • Malignant neoplasm of endometrium of corpus uteri
  • Ovarian cancer
  • PE
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10
Q

Key counselling points

Conjugated estrogens

A
  • Discuss potential long-term adverse effects of hormone therapy including MI, STROKE,DVT, PE, and breast cancer
  • Take at bedtime to minimize side effects
  • Take with/without meals.
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11
Q

ADRs

Estradiol

A

Common:
* 1-10% weight chnage, nausea,vomitng, disturbance in mood,swelling of breast and depression
Rare
* Heart disease,MI,DM,venous theomboembolism,anaphylaxis,cerebrovascular accident,PE,breast,endometrial or ovarian cancer

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12
Q

Key counselling Point

Estradiol

A
  • Report abnormal vaginal bleeding or sign/symptoms of a thromboembolic disorder.
  • Do not smoke during therapy as this increases the risk of thromboembolic events
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13
Q

ADRs

Estradiol transdermal patch

A

> 10%: edema,applicaton site reaction

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14
Q

Brand name

Progesterone

A

Prometrium

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15
Q

Brand name

Medroxyprogesterone

A
  • Provera-oral
  • Depo-Provera injection
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16
Q

Indication

Progesterone

A
  • Preventio of estrogen-induced endometrial hyperplasia(oral) while conjugated estrogens are administered
  • Secondary physiologic amenorrhea(oral or gel)
  • assisted reproduction for infertile women(gel/insert)
17
Q

MOA

Progesterone

A

Transforms proliferative emdometrium into secretory endometrium.Systemically administered progesterone inhibits gonadotropin production ,which in turn prevents follicular maturation and ovulation

18
Q

Major Contraindication

Progesterone

A
  • Abnormal vaginal bleesing
  • History of estrogen or progesterone-dependent neoplasia
  • Active or history of DVT or PE
  • Known or suspected pregnancy
19
Q

BBW

Progesterone

A

Should not be used for the prevention of cardiovascular disorders, dementia or breast cancer

20
Q

ADRs(common)

Progesterone

A
  • > 10%: weight changes,headache,amenorrhea,breat tenderness, abdominal pain
  • 1-10%: nausea,asthenia,feeling nervous,break through bleeding
21
Q

ADRs(rare)

Progesterone

A
  • thromboembolism(DVT,PE)
  • thrombophlebitis
  • osteoporosis
22
Q

Key counselling points

Progesterone

A

If using for amenorrhea, menstrual bleeding should occur 3-7 d after last oral dose.Report if menstruation does not occur within 7 d after last dose.For vaginal formualtion, avoid using other vaginal drugs within 6 h before or 6h after using

23
Q

Brand name

Ethinny Etradiol/Etongestrel Ring

A

Nuva ring

Top 300 Medications (16 decks)

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