Anitfungals Flashcards
1
Q
Azoles
Drugs in class
A
- Fluconazole
- Ketoconazole
2
Q
Brand name
Fluconazole
A
Diflucan
3
Q
Brand name
Ketoconazole Topical
A
Nizoral
4
Q
MOA
Azole
A
Inhibition of fungal CYP51 to block synthesis of ergosterol, a critical component of the membrane
5
Q
ADRs
Azoles
A
- Headache
- Dru-Drug interaction with other agents metabolized by CYP3A4
6
Q
Contraindications
Azoles
A
- Allergy
- Moderate QT prolongation
- Pregnancy
7
Q
Counselling point
Azoles
A
Can be taken with or without food/water
8
Q
Nyastatin
Drugs in class
A
- Nystatin Oral
- NystatinTopical
9
Q
Brand name
Nystatin Oral
A
Bio-statin
10
Q
Brand name
Nystatin Topical
A
- Mycostatin
- Nyamyc
- Nystop
11
Q
MOA
Nystatin
A
Polyene macrolide that binds and destabilizes fungal cell membrane
12
Q
Contraindication
Nystatin
A
Allergy
13
Q
Counselling Point
Nystatin
A
Can be taken with or without food/water
14
Q
Brand name
Terbinafine
A
Lamisil
15
Q
MOA
Terbinafine
A
Allylamine that inhibits ergosterol synthesis through inhibition of squalene epoxidase to destabilize the fungal cell membrane
