Reproductive

Question 1

Finasteride inhibits

Answer 1

5alpha reductase inhibiting conversion of testosterone to DHT

Question 2

Treatment of preeclampsia

Answer 2

IV Mg sulfate

Question 3

Treatment for endometritis

Answer 3

Gentamycin + clindamycin +/- ampicillin

Question 4

Treatment for endometriosis

Answer 4

NSAID
OCPs
Leuprolide
danazol

Question 5

Treatment of PCOS

Answer 5

Weight reduction
low dose OCPs or medroxyprogesterone
Spironolactone
Clomiphene
Metformin

Question 6

BPH treatment

Answer 6

alpha antagonists–terazosin, tamsulosin

finasteride

Question 7

Leuprolide is both a GnRH

Answer 7

agonist and antagonist

Question 8

When does Leuprolide serve as an agonist

Answer 8

When used in a pulsatile fashion

Question 9

When does leuprolide serve as an antagonist

Consequence?

Answer 9

When used in a continuous fashion

It reduces FSH and LH

Question 10

Leuprolide uses

Answer 10

Pulsitile–infertility

Continous(with Flutamide) for Prostate CA, Uterine fibroids, precocious puberty

Question 11

Leuprolide toxicity

Answer 11

Antiandrogen

N/V

Question 12

Testosterone and methyltestosterone MOA

Answer 12

agonist at the androgen receptor

Question 13

Testosterone and methltestosterone uses

Answer 13

Hypogonadism
development of secondary sex characteristics
increase anabolism for recovery after burn or injury

Question 14

Testosterone and methyltestosterone toxicity

Answer 14

masculinization in females
decrease intratesticular T production by InhibitingLh
gonadal atrophy
premature closure of epiphyseal plate
increase LDL and reduce HDL

Question 15

List the antiandrogens

Answer 15

Finasteride
Flutamide
Ketaconazole
Spironolactone

Question 16

finasteride MOA

Answer 16

5 alpha reductase inhibitor reducing conversion of T toDHT

Question 17

Finasteride uses

Answer 17

BPH

Hair growth from male pattern baldness

Question 18

Flutamide MOA

Answer 18

Nonsteroidal competitive inhibitor of androgens at T receptors

Question 19

flutamide uses

Answer 19

Prostate CA

Question 20

Ketoconazole MOA

Answer 20

inhibits steroid synthesis by inhibiting 17,20 desmolase

Question 21

Spironolactone MOA as a antiandrogen

Answer 21

Inhibits steroid binding

Question 22

Ketoconazole and spironolactone uses as antiandrogens and toxicity

Answer 22

PCOS to prevent hirsutism

gynecomastia and amenorrhea

Question 23

List the estrogen drugs and their MOA

Answer 23

ethinyl estradiol
DES
Mestranol
bind estrogen receptors

Question 24

clinical use of the estrogen drugs

Answer 24

Hypogonadism in women
ovarian failure
menstrual abnormalities
As HRT in postmenopausal women
Androgen dependent prostate cancer

Question 25

DES toxicity

Answer 25

clear cell adenocarcinoma of vagina in female fetuses

Question 26

Estrogen drug toxicity

Answer 26

increased R/Of endometrial CA bleeding on Postmenopause increased risk of thrombi

Question 27

Estrogen drugs are contraindicated in

Answer 27

Pts with H/O DVTs | Estrogen positive BCA

Question 28

List the SERMS

Answer 28

Clomiphene Tamoxifen Raloxifene

Question 29

Clomiphene

Answer 29

Partial agonist at estrogen receptor in hypothalamus | prevent Neg FB and Increase LSH and FSH---ovualtion

Question 30

clomiphene uses

Answer 30

PCOS | infertility

Question 31

clomiphene toxicity

Answer 31

hot flashes ovarian enlargement multiple simultaneous pregenacies visual disturbances

Question 32

Tamoxifen MOA and use

Answer 32

antagonist at breast | ER positive BCA

Question 33

Raloxifene MOA and use

Answer 33

agonist at the bone | osteoporosis

Question 34

Hormone replacement therapy (HRT) used for

Answer 34

reducing menopausal SXs | osteoporosis---increased estrogen decrease osteoclast activity

Question 35

HRT toxicity

Answer 35

when unopposed--R/of endometrial CA | also maybe increased risk of CV problems

Question 36

Anastrozole MOA and use

Answer 36

Aromatase inhibitor | postmenopausal pts with BCA

Question 37

Progestins MOA

Answer 37

Bind P receptors and reduce growth and increase vascularization of the endometrium

Question 38

Progestin uses

Answer 38

OCPS Endometrial CA abnormal uterine bleeding

Question 39

Mifepristone(RU-486) MOA and uses

Answer 39

Competitive Progesterone receptors | Termination of Preg---given with misoprostol

Question 40

Mifepristone toxicity

Answer 40

Heavy bleeding | GI effects--N/V/anorexia/abd pain

Question 41

Estrogen component of OCP MOA

Answer 41

inhibits FSH/LH--no ovulation

Question 42

Progestine component of OCPMOA

Answer 42

Thickens cervical mucus---prevent access of sperm | inhibits endometrium proliferation

Question 43

Combo E&P OCP contraindicated in

Answer 43

Smokers >35 Pts with h/o thromboemolism or stroke h/o of estrogen dependent tumor

Question 44

Terbutaline MOA and use

Answer 44

Beta 2 agonist that relaxes the uterus | to reduce premature uterine contractions

Question 45

Tamsulosin MOA and use

Answer 45

alpha 1 antagonist--inhibit smooth muscle contraction | BPH

Question 46

What subset of alpha1 receptor does tamsulosin work on and why is this important

Answer 46

Alpha 1 A,D found in prostate | vs Alpha1B found on vasculature

Question 47

Sildenafil and vardenafil MOA

Answer 47

Inhibits phosphodiesterase 5 causing increased cGMP= SM relaxation increased BF increased erection

Question 48

Sildenafil and verdenafil use

Answer 48

Erectile dysfunction

Question 49

Sildenafil and verdenafil toxicity

Answer 49

HA Flushing dyspepsia impaired blue-green color vision

Question 50

Don't take Sildenafil and Vardenafil with the following

Answer 50

Nitrates---lead to life threatening hyptotension

Question 51

Danazol MOA

Answer 51

Synthetic androgen --acts as a partial agonistat androgen receptors

Question 52

Danazol MOA

Answer 52

Endometriosis and hereditary angioedema

Question 53

Danazol toxicity

Answer 53

``` Weight gain edema acne hirsutism masculinization reduceHDL hepatoxicity ```