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Pharmacology > Reproductive > Flashcards

Reproductive Flashcards

1
Q

Finasteride inhibits

A

5alpha reductase inhibiting conversion of testosterone to DHT

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2
Q

Treatment of preeclampsia

A

IV Mg sulfate

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3
Q

Treatment for endometritis

A

Gentamycin + clindamycin +/- ampicillin

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4
Q

Treatment for endometriosis

A

NSAID
OCPs
Leuprolide
danazol

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5
Q

Treatment of PCOS

A 
Weight reduction
low dose OCPs or medroxyprogesterone
Spironolactone
Clomiphene
Metformin
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6
Q

BPH treatment

A

alpha antagonists–terazosin, tamsulosin

finasteride

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7
Q

Leuprolide is both a GnRH

A

agonist and antagonist

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8
Q

When does Leuprolide serve as an agonist

A

When used in a pulsatile fashion

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9
Q

When does leuprolide serve as an antagonist

Consequence?

A

When used in a continuous fashion

It reduces FSH and LH

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10
Q

Leuprolide uses

A

Pulsitile–infertility

Continous(with Flutamide) for Prostate CA, Uterine fibroids, precocious puberty

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11
Q

Leuprolide toxicity

A

Antiandrogen

N/V

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12
Q

Testosterone and methyltestosterone MOA

A

agonist at the androgen receptor

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13
Q

Testosterone and methltestosterone uses

A

Hypogonadism
development of secondary sex characteristics
increase anabolism for recovery after burn or injury

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14
Q

Testosterone and methyltestosterone toxicity

A 
masculinization in females
decrease intratesticular T production by InhibitingLh
gonadal atrophy
premature closure of epiphyseal plate
increase LDL and reduce HDL
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15
Q

List the antiandrogens

A

Finasteride
Flutamide
Ketaconazole
Spironolactone

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16
Q

finasteride MOA

A

5 alpha reductase inhibitor reducing conversion of T toDHT

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17
Q

Finasteride uses

A

BPH

Hair growth from male pattern baldness

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18
Q

Flutamide MOA

A

Nonsteroidal competitive inhibitor of androgens at T receptors

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19
Q

flutamide uses

A

Prostate CA

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20
Q

Ketoconazole MOA

A

inhibits steroid synthesis by inhibiting 17,20 desmolase

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21
Q

Spironolactone MOA as a antiandrogen

A

Inhibits steroid binding

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22
Q

Ketoconazole and spironolactone uses as antiandrogens and toxicity

A

PCOS to prevent hirsutism

gynecomastia and amenorrhea

23
Q

List the estrogen drugs and their MOA

A

ethinyl estradiol
DES
Mestranol
bind estrogen receptors

24
Q

clinical use of the estrogen drugs

A 
Hypogonadism in women
ovarian failure
menstrual abnormalities
As HRT in postmenopausal women
Androgen dependent prostate cancer
25
Q

DES toxicity

A

clear cell adenocarcinoma of vagina in female fetuses

26
Q

Estrogen drug toxicity

A

increased R/Of endometrial CA
bleeding on Postmenopause
increased risk of thrombi

27
Q

Estrogen drugs are contraindicated in

A

Pts with H/O DVTs

Estrogen positive BCA

28
Q

List the SERMS

A

Clomiphene
Tamoxifen
Raloxifene

29
Q

Clomiphene

A

Partial agonist at estrogen receptor in hypothalamus

prevent Neg FB and Increase LSH and FSH—ovualtion

30
Q

clomiphene uses

A

PCOS

infertility

31
Q

clomiphene toxicity

A

hot flashes
ovarian enlargement
multiple simultaneous pregenacies
visual disturbances

32
Q

Tamoxifen MOA and use

A

antagonist at breast

ER positive BCA

33
Q

Raloxifene MOA and use

A

agonist at the bone

osteoporosis

34
Q

Hormone replacement therapy (HRT) used for

A

reducing menopausal SXs

osteoporosis—increased estrogen decrease osteoclast activity

35
Q

HRT toxicity

A

when unopposed–R/of endometrial CA

also maybe increased risk of CV problems

36
Q

Anastrozole MOA and use

A

Aromatase inhibitor

postmenopausal pts with BCA

37
Q

Progestins MOA

A

Bind P receptors and reduce growth and increase vascularization of the endometrium

38
Q

Progestin uses

A

OCPS
Endometrial CA
abnormal uterine bleeding

39
Q

Mifepristone(RU-486) MOA and uses

A

Competitive Progesterone receptors

Termination of Preg—given with misoprostol

40
Q

Mifepristone toxicity

A

Heavy bleeding

GI effects–N/V/anorexia/abd pain

41
Q

Estrogen component of OCP MOA

A

inhibits FSH/LH–no ovulation

42
Q

Progestine component of OCPMOA

A

Thickens cervical mucus—prevent access of sperm

inhibits endometrium proliferation

43
Q

Combo E&P OCP contraindicated in

A

Smokers >35
Pts with h/o thromboemolism or stroke
h/o of estrogen dependent tumor

44
Q

Terbutaline MOA and use

A

Beta 2 agonist that relaxes the uterus

to reduce premature uterine contractions

45
Q

Tamsulosin MOA and use

A

alpha 1 antagonist–inhibit smooth muscle contraction

BPH

46
Q

What subset of alpha1 receptor does tamsulosin work on and why is this important

A

Alpha 1 A,D found in prostate

vs Alpha1B found on vasculature

47
Q

Sildenafil and vardenafil MOA

A

Inhibits phosphodiesterase 5 causing increased cGMP=
SM relaxation
increased BF
increased erection

48
Q

Sildenafil and verdenafil use

A

Erectile dysfunction

49
Q

Sildenafil and verdenafil toxicity

A

HA
Flushing
dyspepsia
impaired blue-green color vision

50
Q

Don’t take Sildenafil and Vardenafil with the following

A

Nitrates—lead to life threatening hyptotension

51
Q

Danazol MOA

A

Synthetic androgen –acts as a partial agonistat androgen receptors

52
Q

Danazol MOA

A

Endometriosis and hereditary angioedema

53
Q

Danazol toxicity

A 
Weight gain
edema
acne
hirsutism
masculinization
reduceHDL
hepatoxicity

Pharmacology (13 decks)

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