MSK/DERM

Question 1

Treatment of osteoporosis

Answer 1

SERMS w/without Calcitonin
Bisphosphonates
pulsatile PTH–for severe

Question 2

treatment of Paget’s disease

Answer 2

Calcitonin

Bisphosphate

Question 3

Treatment of osteoarthritis

Answer 3

NSAIDS

Intra-articular glucocorticoids

Question 4

Rheumatoid arthritis

Answer 4

NSAIDs
Glucocorticoid
Disease modifying agents—
Methotrexate, sulfasalazine, TNF-alpha inhibitors

Question 5

Treatment of acute Gout

Answer 5

NSAID–Indomethacin

Glucocorticoids

Question 6

Treatment of chronic Gout

Answer 6

Xanthine oxidase inhibitors like allopurinol and febuxostat

Question 7

Treatment for overproduction Gout

Answer 7

Probenecid

Question 8

treatment of BRAF V600E mutation Melanoma

Answer 8

Vemurafenib–a BRAF kinase inhibitor

Question 9

Draw the Arachidonic acid pathway

Answer 9

:)

Question 10

ASA MOAs

Answer 10

irreverbibly inhibits cylcloxygenase 1 and 2 by acetylation
decreasing syn of TXA2
Prostaglandins

Question 11

ASA increases ___but not___

Answer 11

Bleeding time

not PT/PTT

Question 12

ASA use

Answer 12

Low dose–inhibit PLT aggregation
Intermediate dose–pain and fever
High dose–anti-inflammatory

Question 13

ASA toxicity

Answer 13

Tinnitus
Gastric ulceration
Acute renal failure with chronic use
interstitial nephritis
upper GI bleeding
stimulats resp centers--hypervent and resp alkalosis
Reye's syndrome

Question 14

List the NSAIDS

Answer 14

Ibuprofen
Naproxen
Indomethacin
Ketorolac
diclofenac

Question 15

NSAID MOA

Answer 15

REVERSIBLY inhibits COX1 and 2

blocks prostaglandin synthesis

Question 16

Indomethacin is used to close

Answer 16

PDA

Question 17

NSAID toxicty

Answer 17

Interstitial nephritis
gastric ulcer—PGs are GI mucosa protective
renal ischemia—PGs VD the afferent arterioles

Question 18

List the Cox-2 inhibitor

Answer 18

celecoxib

Question 19

Celecoxib MOA

Answer 19

REVERSIBLY inhiibits Cox2

Spares gastric mucosa and Plt function

Question 20

Celecoxib use

Answer 20

PA
Osteoarthritis
gastritis
ulcer

Question 21

Celecoxib toxicity

Answer 21

increase r/of thrombosis

sulfa allergy

Question 22

Acetaminophen MOA

Answer 22

REVERSILBY inhibit COX 1&2 mostly in the CNS

Question 23

Acetaminophen is inactivated

Answer 23

peripherally

Question 24

Acetaminophen toxicity

Answer 24

Overdose–hepatic necrosis

depletes gluthathione forming toxic tissue adducts in liver

Question 25

Acetaminophen anecdote

Answer 25

N-acetylcysteine

Question 26

Name the bisphosphates

Answer 26

Alendronate | other dronates

Question 27

bispohosphate MOA

Answer 27

pyrophosphate analogs that bind hydroxyapetite in bone and inhibit osteoclast activity

Question 28

bisphophate toxicity

Answer 28

corrosive esophagitis | osteonecrosis

Question 29

Allopurinol MOA

Answer 29

xanthine oxidase inhibitor | increase the conc of azathioprine and 6-MP which are metabolized by xanthine oxidase

Question 30

Allopurinol use

Answer 30

Gout | tumor lysis syndrome

Question 31

Febuxostat MOA

Answer 31

inhibits xanthine oxidase

Question 32

Probenecid MOA

Answer 32

inhibits RAB of uric acid in PCT | increases secretion of PCN

Question 33

Colchicine MOA

Answer 33

binds and stabilizes tubulin to inhibit polymerization impairing leukocyte chemotaxis and degranulation

Question 34

Colchicine use and toxicity

Answer 34

chronic gout | GI side effects

Question 35

List the TNF alpha inhibitors

Answer 35

Etanercept infliximab adalimumab

Question 36

Etanercept MOA

Answer 36

produced by recombinat DNA--fusion protein--receptor for TNF alpha + IgG fc

Question 37

Etanercept uses

Answer 37

RA Psoriasis AS

Question 38

Infliximab/adalimumab MOA and use

Answer 38

``` anti-TNF alfa Crohn's RA AS psoriasis ```